Cargando…

Investigation of the Josephin Domain Protein-Protein Interaction by Molecular Dynamics

Spinocerebellar ataxia (SCA) 3, the most common form of SCA, is a neurodegenerative rare disease characterized by polyglutamine tract expansion and self-assembly of Ataxin3 (At3) misfolded proteins into highly organized fibrillar aggregates. The At3 N-terminal Josephin Domain (JD) has been suggested...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deriu, Marco A., Grasso, Gianvito, Licandro, Ginevra, Danani, Andrea, Gallo, Diego, Tuszynski, Jack A., Morbiducci, Umberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182536/ https://www.ncbi.nlm.nih.gov/pubmed/25268243 http://dx.doi.org/10.1371/journal.pone.0108677

Ejemplares similares

Thermodynamic and kinetic stability of the Josephin Domain closed arrangement: evidences from replica exchange molecular dynamics
por: Grasso, Gianvito, et al.
Publicado: (2017)

Josephin Domain Structural Conformations Explored by Metadynamics in Essential Coordinates
por: Deriu, Marco A., et al.
Publicado: (2016)

Conformational Dynamics and Stability of U-Shaped and S-Shaped Amyloid β Assemblies
por: Grasso, Gianvito, et al.
Publicado: (2018)

The Role of Structural Polymorphism in Driving the Mechanical Performance of the Alzheimer's Beta Amyloid Fibrils
por: Grasso, Gianvito, et al.
Publicado: (2019)

Protein Environment: A Crucial Triggering Factor in Josephin Domain Aggregation: The Role of 2,2,2-Trifluoroethanol
por: Visentin, Cristina, et al.
Publicado: (2018)

Insights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA
por: Lepre, Marco Gaetano, et al.
Publicado: (2017)

Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations
por: Gentile, Francesco, et al.
Publicado: (2015)

Josephine Snetsinger
Publicado: (1905)

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
por: Pallante, Lorenzo, et al.
Publicado: (2020)

Virtual screening using covalent docking to find activators for G245S mutant p53
por: Omar, Sara Ibrahim, et al.
Publicado: (2018)

A Novel Interaction Between the TLR7 and a Colchicine Derivative Revealed Through a Computational and Experimental Study
por: Gentile, Francesco, et al.
Publicado: (2018)

Free energy landscape of siRNA-polycation complexation: Elucidating the effect of molecular geometry, polymer flexibility, and charge neutralization
por: Grasso, Gianvito, et al.
Publicado: (2017)

The Impact of Natural Compounds on S-Shaped Aβ42 Fibril: From Molecular Docking to Biophysical Characterization
por: Muscat, Stefano, et al.
Publicado: (2020)

Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3
por: Sanfelice, Domenico, et al.
Publicado: (2014)

Memoirs of the Empress Josephine
por: Rémusat, Madame de (Claire Elisabeth Jeanne Gravier de Vergennes), 1780-1821
Publicado: (1910)

A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected
por: Apicella, Alessandra, et al.
Publicado: (2013)

Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3()
por: Faggiano, Serena, et al.
Publicado: (2013)

In silico investigation of cytochrome bc1 molecular inhibition mechanism against Trypanosoma cruzi
por: Muscat, Stefano, et al.
Publicado: (2023)

Characterization of the Interaction of Polymeric Micelles with siRNA: A Combined Experimental and Molecular Dynamics Study
por: Marquet, Franck, et al.
Publicado: (2022)

Explaining the Microtubule Energy Balance: Contributions Due to Dipole Moments, Charges, van der Waals and Solvation Energy
por: Ayoub, Ahmed Taha, et al.
Publicado: (2017)

Los relatos de Basil y Josephine
por: Fitzgerald, F. Scott (Francis Scott), 1896-1940
Publicado: (1977)

Understanding the Role of the Josephin Domain in the PolyUb Binding and Cleavage Properties of Ataxin-3
por: Nicastro, Giuseppe, et al.
Publicado: (2010)

Structural insights into the activity and regulation of human Josephin-2
por: Grasty, Kimberly C., et al.
Publicado: (2019)

Molecular and Coarse-Grained Modeling to Characterize and Optimize Dendrimer-Based Nanocarriers for Short Interfering RNA Delivery
por: Stojceski, Filip, et al.
Publicado: (2020)

Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations
por: Zizzi, Eric A., et al.
Publicado: (2022)

Meeting the governance challenges of integrated health and social care: Josephine Exley
por: Exley, J, et al.
Publicado: (2022)

Prediction of Protein–Protein Interactions Between Alsin DH/PH and Rac1 and Resulting Protein Dynamics
por: Cannariato, Marco, et al.
Publicado: (2022)

A Versatile Bioreactor for Dynamic Suspension Cell Culture. Application to the Culture of Cancer Cell Spheroids
por: Massai, Diana, et al.
Publicado: (2016)

The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
por: Formicola, Beatrice, et al.
Publicado: (2019)

The Woman’s Peril; the Man’s Sin: Letter from Dr. Josephine Kingsley
Publicado: (1904)

Computational Investigation of the Ordered Water System Around Microtubules: Implications for Protein Interactions
por: Chierici, Francesco, et al.
Publicado: (2022)

The Josephin domain (JD) containing proteins are predicted to bind to the same interactors: Implications for spinocerebellar ataxia type 3 (SCA3) studies using Drosophila melanogaster mutants
por: Sousa e Silva, Rita, et al.
Publicado: (2023)

The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro
por: Dal Magro, Roberta, et al.
Publicado: (2019)

When Stiffness Matters: Mechanosensing in Heart Development and Disease
por: Gaetani, Roberto, et al.
Publicado: (2020)

Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions
por: Delaforge, Elise, et al.
Publicado: (2016)

Informed classification of sweeteners/bitterants compounds via explainable machine learning
por: Maroni, Gabriele, et al.
Publicado: (2022)

Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore
por: Trofimenko, Evgeniya, et al.
Publicado: (2021)

Personalized therapy design for systemic lupus erythematosus based on the analysis of protein-protein interaction networks
por: Brant, Elizabeth J., et al.
Publicado: (2020)

Computational fluid dynamics as supporting technology for coronary artery disease diagnosis and treatment: an international survey
por: Chiastra, Claudio, et al.
Publicado: (2023)

Using the Gibbs Function as a Measure of Human Brain Development Trends from Fetal Stage to Advanced Age
por: Rietman, Edward A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_49r75c1vongk4lcmorrmvatfpe