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Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment

CONTEXT: Clomiphene citrate (CC) is the first line drug for ovulation induction but because of its peripheral antiestrogenic effect, letrozole was introduced as the 2(nd) line drug. It lacks the peripheral antiestrogenic effect and is associated with similar or even higher pregnancy rates. Since let...

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Autores principales: Sharma, Sunita, Ghosh, Sanghamitra, Singh, Soma, Chakravarty, Astha, Ganesh, Ashalatha, Rajani, Shweta, Chakravarty, B. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182712/
https://www.ncbi.nlm.nih.gov/pubmed/25272289
http://dx.doi.org/10.1371/journal.pone.0108219
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author Sharma, Sunita
Ghosh, Sanghamitra
Singh, Soma
Chakravarty, Astha
Ganesh, Ashalatha
Rajani, Shweta
Chakravarty, B. N.
author_facet Sharma, Sunita
Ghosh, Sanghamitra
Singh, Soma
Chakravarty, Astha
Ganesh, Ashalatha
Rajani, Shweta
Chakravarty, B. N.
author_sort Sharma, Sunita
collection PubMed
description CONTEXT: Clomiphene citrate (CC) is the first line drug for ovulation induction but because of its peripheral antiestrogenic effect, letrozole was introduced as the 2(nd) line drug. It lacks the peripheral antiestrogenic effect and is associated with similar or even higher pregnancy rates. Since letrozole is a drug for breast cancer, its use for the purpose of ovulation induction became controversial in the light of studies indicating an increased incidence of congenital malformations. AIMS: To evaluate and compare the incidence of congenital malformations among offsprings of infertile couples who conceived naturally or with clomiphene citrate or letrozole treatment. SETTINGS AND DESIGN: A retrospective cohort study done at a tertiary infertility centre. METHODS AND MATERIAL: A total of 623 children born to infertile women who conceived naturally or following clomiphene citrate or letrozole treatment were included in this study. Subjects were sorted out from medical files of both mother and newborn and follow up study was done based on the information provided by parents through telephonic conversations. Babies with suspected anomaly were called and examined by specialists for the presence of major and minor congenital malformations. Other outcomes like multiple pregnancy rate and birth weight were also studied. RESULTS: Overall, congenital malformations, chromosomal abnormalities were found in 5 out of 171 (2.9%) babies in natural conception group and 5 out of 201 babies in the letrozole group (2.5%) and in 10 of 251 babies in the CC group (3.9%). CONCLUSIONS: There was no significant difference in the overall rate of congenital malformations among children born to mothers who conceived naturally or after letrozole or CC treatment. KEY MESSAGES: Congenital malformations have been found to be comparable following natural conception, letrozole and clomiphene citrate. Thus, the undue fear against letrozole may be uncalled for.
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spelling pubmed-41827122014-10-07 Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment Sharma, Sunita Ghosh, Sanghamitra Singh, Soma Chakravarty, Astha Ganesh, Ashalatha Rajani, Shweta Chakravarty, B. N. PLoS One Research Article CONTEXT: Clomiphene citrate (CC) is the first line drug for ovulation induction but because of its peripheral antiestrogenic effect, letrozole was introduced as the 2(nd) line drug. It lacks the peripheral antiestrogenic effect and is associated with similar or even higher pregnancy rates. Since letrozole is a drug for breast cancer, its use for the purpose of ovulation induction became controversial in the light of studies indicating an increased incidence of congenital malformations. AIMS: To evaluate and compare the incidence of congenital malformations among offsprings of infertile couples who conceived naturally or with clomiphene citrate or letrozole treatment. SETTINGS AND DESIGN: A retrospective cohort study done at a tertiary infertility centre. METHODS AND MATERIAL: A total of 623 children born to infertile women who conceived naturally or following clomiphene citrate or letrozole treatment were included in this study. Subjects were sorted out from medical files of both mother and newborn and follow up study was done based on the information provided by parents through telephonic conversations. Babies with suspected anomaly were called and examined by specialists for the presence of major and minor congenital malformations. Other outcomes like multiple pregnancy rate and birth weight were also studied. RESULTS: Overall, congenital malformations, chromosomal abnormalities were found in 5 out of 171 (2.9%) babies in natural conception group and 5 out of 201 babies in the letrozole group (2.5%) and in 10 of 251 babies in the CC group (3.9%). CONCLUSIONS: There was no significant difference in the overall rate of congenital malformations among children born to mothers who conceived naturally or after letrozole or CC treatment. KEY MESSAGES: Congenital malformations have been found to be comparable following natural conception, letrozole and clomiphene citrate. Thus, the undue fear against letrozole may be uncalled for. Public Library of Science 2014-10-01 /pmc/articles/PMC4182712/ /pubmed/25272289 http://dx.doi.org/10.1371/journal.pone.0108219 Text en © 2014 Sharma et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sharma, Sunita
Ghosh, Sanghamitra
Singh, Soma
Chakravarty, Astha
Ganesh, Ashalatha
Rajani, Shweta
Chakravarty, B. N.
Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
title Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
title_full Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
title_fullStr Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
title_full_unstemmed Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
title_short Congenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
title_sort congenital malformations among babies born following letrozole or clomiphene for infertility treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182712/
https://www.ncbi.nlm.nih.gov/pubmed/25272289
http://dx.doi.org/10.1371/journal.pone.0108219
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