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Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182716/ https://www.ncbi.nlm.nih.gov/pubmed/25272046 http://dx.doi.org/10.1371/journal.pone.0108543 |
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author | Miyagi, Mariana Yasue Saito Seelaender, Marilia Castoldi, Angela de Almeida, Danilo Candido Bacurau, Aline Villa Nova Andrade-Oliveira, Vinicius Enjiu, Lucas Maceratesi Pisciottano, Marcus Hayashida, Caroline Yuri Hiyane, Meire Ioshie Brum, Patricia Chakur Camara, Niels Olsen Saraiva Amano, Mariane Tami |
author_facet | Miyagi, Mariana Yasue Saito Seelaender, Marilia Castoldi, Angela de Almeida, Danilo Candido Bacurau, Aline Villa Nova Andrade-Oliveira, Vinicius Enjiu, Lucas Maceratesi Pisciottano, Marcus Hayashida, Caroline Yuri Hiyane, Meire Ioshie Brum, Patricia Chakur Camara, Niels Olsen Saraiva Amano, Mariane Tami |
author_sort | Miyagi, Mariana Yasue Saito |
collection | PubMed |
description | Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors. However, little is known about the impact of physical exercise on cisplatin-induced acute kidney injury (AKI). In the present study, our aim was to investigate the role of physical exercise in AKI induced by cisplatin. We submitted C57Bl6 male mice to seven weeks of chronic exercise on a training treadmill and treated them with single i.p. injection of cisplatin (20 mg/kg) in the last week. Exercise efficacy was confirmed by an increased capillary-to-fiber ratio in the gastrocnemius muscle of exercised groups (EX and CIS-EX). The group submitted to exercise before cisplatin administration (CIS-EX) exhibited less weight loss and decreased serum urea levels compared to the cisplatin group (CIS). Exercise also showed a protective role against cisplatin-induced cell death in the kidney. The CIS-EX group showed a lower inflammatory response, with less TNF and IL-10 expression in the kidney and serum. In the same group, we observed an increase of IL-6 and HO-1 expression in the kidney. Taken together, our results indicate that chronic aerobic exercise is able to attenuate AKI by inducing IL-6 and HO-1 production, which results in lower inflammatory and apoptotic profiles in the kidney. |
format | Online Article Text |
id | pubmed-4182716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41827162014-10-07 Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 Miyagi, Mariana Yasue Saito Seelaender, Marilia Castoldi, Angela de Almeida, Danilo Candido Bacurau, Aline Villa Nova Andrade-Oliveira, Vinicius Enjiu, Lucas Maceratesi Pisciottano, Marcus Hayashida, Caroline Yuri Hiyane, Meire Ioshie Brum, Patricia Chakur Camara, Niels Olsen Saraiva Amano, Mariane Tami PLoS One Research Article Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors. However, little is known about the impact of physical exercise on cisplatin-induced acute kidney injury (AKI). In the present study, our aim was to investigate the role of physical exercise in AKI induced by cisplatin. We submitted C57Bl6 male mice to seven weeks of chronic exercise on a training treadmill and treated them with single i.p. injection of cisplatin (20 mg/kg) in the last week. Exercise efficacy was confirmed by an increased capillary-to-fiber ratio in the gastrocnemius muscle of exercised groups (EX and CIS-EX). The group submitted to exercise before cisplatin administration (CIS-EX) exhibited less weight loss and decreased serum urea levels compared to the cisplatin group (CIS). Exercise also showed a protective role against cisplatin-induced cell death in the kidney. The CIS-EX group showed a lower inflammatory response, with less TNF and IL-10 expression in the kidney and serum. In the same group, we observed an increase of IL-6 and HO-1 expression in the kidney. Taken together, our results indicate that chronic aerobic exercise is able to attenuate AKI by inducing IL-6 and HO-1 production, which results in lower inflammatory and apoptotic profiles in the kidney. Public Library of Science 2014-10-01 /pmc/articles/PMC4182716/ /pubmed/25272046 http://dx.doi.org/10.1371/journal.pone.0108543 Text en © 2014 Miyagi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Miyagi, Mariana Yasue Saito Seelaender, Marilia Castoldi, Angela de Almeida, Danilo Candido Bacurau, Aline Villa Nova Andrade-Oliveira, Vinicius Enjiu, Lucas Maceratesi Pisciottano, Marcus Hayashida, Caroline Yuri Hiyane, Meire Ioshie Brum, Patricia Chakur Camara, Niels Olsen Saraiva Amano, Mariane Tami Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 |
title | Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 |
title_full | Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 |
title_fullStr | Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 |
title_full_unstemmed | Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 |
title_short | Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 |
title_sort | long-term aerobic exercise protects against cisplatin-induced nephrotoxicity by modulating the expression of il-6 and ho-1 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182716/ https://www.ncbi.nlm.nih.gov/pubmed/25272046 http://dx.doi.org/10.1371/journal.pone.0108543 |
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