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Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1

Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors....

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Autores principales: Miyagi, Mariana Yasue Saito, Seelaender, Marilia, Castoldi, Angela, de Almeida, Danilo Candido, Bacurau, Aline Villa Nova, Andrade-Oliveira, Vinicius, Enjiu, Lucas Maceratesi, Pisciottano, Marcus, Hayashida, Caroline Yuri, Hiyane, Meire Ioshie, Brum, Patricia Chakur, Camara, Niels Olsen Saraiva, Amano, Mariane Tami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182716/
https://www.ncbi.nlm.nih.gov/pubmed/25272046
http://dx.doi.org/10.1371/journal.pone.0108543
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author Miyagi, Mariana Yasue Saito
Seelaender, Marilia
Castoldi, Angela
de Almeida, Danilo Candido
Bacurau, Aline Villa Nova
Andrade-Oliveira, Vinicius
Enjiu, Lucas Maceratesi
Pisciottano, Marcus
Hayashida, Caroline Yuri
Hiyane, Meire Ioshie
Brum, Patricia Chakur
Camara, Niels Olsen Saraiva
Amano, Mariane Tami
author_facet Miyagi, Mariana Yasue Saito
Seelaender, Marilia
Castoldi, Angela
de Almeida, Danilo Candido
Bacurau, Aline Villa Nova
Andrade-Oliveira, Vinicius
Enjiu, Lucas Maceratesi
Pisciottano, Marcus
Hayashida, Caroline Yuri
Hiyane, Meire Ioshie
Brum, Patricia Chakur
Camara, Niels Olsen Saraiva
Amano, Mariane Tami
author_sort Miyagi, Mariana Yasue Saito
collection PubMed
description Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors. However, little is known about the impact of physical exercise on cisplatin-induced acute kidney injury (AKI). In the present study, our aim was to investigate the role of physical exercise in AKI induced by cisplatin. We submitted C57Bl6 male mice to seven weeks of chronic exercise on a training treadmill and treated them with single i.p. injection of cisplatin (20 mg/kg) in the last week. Exercise efficacy was confirmed by an increased capillary-to-fiber ratio in the gastrocnemius muscle of exercised groups (EX and CIS-EX). The group submitted to exercise before cisplatin administration (CIS-EX) exhibited less weight loss and decreased serum urea levels compared to the cisplatin group (CIS). Exercise also showed a protective role against cisplatin-induced cell death in the kidney. The CIS-EX group showed a lower inflammatory response, with less TNF and IL-10 expression in the kidney and serum. In the same group, we observed an increase of IL-6 and HO-1 expression in the kidney. Taken together, our results indicate that chronic aerobic exercise is able to attenuate AKI by inducing IL-6 and HO-1 production, which results in lower inflammatory and apoptotic profiles in the kidney.
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spelling pubmed-41827162014-10-07 Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1 Miyagi, Mariana Yasue Saito Seelaender, Marilia Castoldi, Angela de Almeida, Danilo Candido Bacurau, Aline Villa Nova Andrade-Oliveira, Vinicius Enjiu, Lucas Maceratesi Pisciottano, Marcus Hayashida, Caroline Yuri Hiyane, Meire Ioshie Brum, Patricia Chakur Camara, Niels Olsen Saraiva Amano, Mariane Tami PLoS One Research Article Nephrotoxicity is substantial side effect for 30% of patients undergoing cancer therapy with cisplatin and may force them to change or even abandon the treatment. Studies regarding aerobic exercise have shown its efficacy for the treatment of many types of diseases and its capacity to reduce tumors. However, little is known about the impact of physical exercise on cisplatin-induced acute kidney injury (AKI). In the present study, our aim was to investigate the role of physical exercise in AKI induced by cisplatin. We submitted C57Bl6 male mice to seven weeks of chronic exercise on a training treadmill and treated them with single i.p. injection of cisplatin (20 mg/kg) in the last week. Exercise efficacy was confirmed by an increased capillary-to-fiber ratio in the gastrocnemius muscle of exercised groups (EX and CIS-EX). The group submitted to exercise before cisplatin administration (CIS-EX) exhibited less weight loss and decreased serum urea levels compared to the cisplatin group (CIS). Exercise also showed a protective role against cisplatin-induced cell death in the kidney. The CIS-EX group showed a lower inflammatory response, with less TNF and IL-10 expression in the kidney and serum. In the same group, we observed an increase of IL-6 and HO-1 expression in the kidney. Taken together, our results indicate that chronic aerobic exercise is able to attenuate AKI by inducing IL-6 and HO-1 production, which results in lower inflammatory and apoptotic profiles in the kidney. Public Library of Science 2014-10-01 /pmc/articles/PMC4182716/ /pubmed/25272046 http://dx.doi.org/10.1371/journal.pone.0108543 Text en © 2014 Miyagi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Miyagi, Mariana Yasue Saito
Seelaender, Marilia
Castoldi, Angela
de Almeida, Danilo Candido
Bacurau, Aline Villa Nova
Andrade-Oliveira, Vinicius
Enjiu, Lucas Maceratesi
Pisciottano, Marcus
Hayashida, Caroline Yuri
Hiyane, Meire Ioshie
Brum, Patricia Chakur
Camara, Niels Olsen Saraiva
Amano, Mariane Tami
Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
title Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
title_full Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
title_fullStr Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
title_full_unstemmed Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
title_short Long-Term Aerobic Exercise Protects against Cisplatin-Induced Nephrotoxicity by Modulating the Expression of IL-6 and HO-1
title_sort long-term aerobic exercise protects against cisplatin-induced nephrotoxicity by modulating the expression of il-6 and ho-1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182716/
https://www.ncbi.nlm.nih.gov/pubmed/25272046
http://dx.doi.org/10.1371/journal.pone.0108543
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