Tempol, a Superoxide Dismutase Mimetic Agent, Ameliorates Cisplatin-Induced Nephrotoxicity through Alleviation of Mitochondrial Dysfunction in Mice

BACKGROUND: Mitochondrial dysfunction is a crucial mechanism by which cisplatin, a potent chemotherapeutic agent, causes nephrotoxicity where mitochondrial electron transport complexes are shifted mostly toward imbalanced reactive oxygen species versus energy production. In the present study, the pr...

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Detalles Bibliográficos
Autores principales: Ahmed, Lamiaa A., Shehata, Nagwa I., Abdelkader, Noha F., Khattab, Mahmoud M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182751/
https://www.ncbi.nlm.nih.gov/pubmed/25271439
http://dx.doi.org/10.1371/journal.pone.0108889

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