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Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) and autophagy play increasingly important roles in DNA damage repair and cell death. Gemcitabine (GEM) remains the first-line chemotherapeutic drug for pancreatic cancer (PC). However, little is known about the relationship between PARP-1 expression and autoph...

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Detalles Bibliográficos
Autores principales:	Wang, Yufeng, Kuramitsu, Yasuhiro, Tokuda, Kazuhiro, Baron, Byron, Kitagawa, Takao, Akada, Junko, Maehara, Shin-ichiro, Maehara, Yoshihiko, Nakamura, Kazuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182782/ https://www.ncbi.nlm.nih.gov/pubmed/25271986 http://dx.doi.org/10.1371/journal.pone.0109076

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