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Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial membrane inflammation and joint cartilage destruction. Abatacept is a biologic agent that blocks the costimulation signals, preventing antigen presentation and proliferation of T lymphocytes. It is approved for the treatmen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182847/ https://www.ncbi.nlm.nih.gov/pubmed/25313341 http://dx.doi.org/10.1155/2014/835050 |
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author | Ospina, Fabio E. Agualimpia, Andrés Bonilla-Abadía, Fabio Cañas, Carlos A. Tobón, Gabriel J. |
author_facet | Ospina, Fabio E. Agualimpia, Andrés Bonilla-Abadía, Fabio Cañas, Carlos A. Tobón, Gabriel J. |
author_sort | Ospina, Fabio E. |
collection | PubMed |
description | Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial membrane inflammation and joint cartilage destruction. Abatacept is a biologic agent that blocks the costimulation signals, preventing antigen presentation and proliferation of T lymphocytes. It is approved for the treatment of patients with RA. Pneumocystis jirovecii pneumonia (PJP) is an infectious disease complicating several immunosuppressive drugs. PJP associated with abatacept has not been reported yet in the medical literature. Various factors, such as the mechanism of action of abatacept, may contribute to predisposing to Pneumocystis jirovecii infection. In this paper, we report a patient with RA who developed PJP under abatacept treatment. |
format | Online Article Text |
id | pubmed-4182847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41828472014-10-13 Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept Ospina, Fabio E. Agualimpia, Andrés Bonilla-Abadía, Fabio Cañas, Carlos A. Tobón, Gabriel J. Case Rep Rheumatol Case Report Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial membrane inflammation and joint cartilage destruction. Abatacept is a biologic agent that blocks the costimulation signals, preventing antigen presentation and proliferation of T lymphocytes. It is approved for the treatment of patients with RA. Pneumocystis jirovecii pneumonia (PJP) is an infectious disease complicating several immunosuppressive drugs. PJP associated with abatacept has not been reported yet in the medical literature. Various factors, such as the mechanism of action of abatacept, may contribute to predisposing to Pneumocystis jirovecii infection. In this paper, we report a patient with RA who developed PJP under abatacept treatment. Hindawi Publishing Corporation 2014 2014-09-17 /pmc/articles/PMC4182847/ /pubmed/25313341 http://dx.doi.org/10.1155/2014/835050 Text en Copyright © 2014 Fabio E. Ospina et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ospina, Fabio E. Agualimpia, Andrés Bonilla-Abadía, Fabio Cañas, Carlos A. Tobón, Gabriel J. Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept |
title |
Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept |
title_full |
Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept |
title_fullStr |
Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept |
title_full_unstemmed |
Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept |
title_short |
Pneumocystis jirovecii Pneumonia in a Patient with Rheumatoid Arthritis Treated with Abatacept |
title_sort | pneumocystis jirovecii pneumonia in a patient with rheumatoid arthritis treated with abatacept |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182847/ https://www.ncbi.nlm.nih.gov/pubmed/25313341 http://dx.doi.org/10.1155/2014/835050 |
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