Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β/AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling

Glucocorticoid (GC) therapies may adversely cause insulin resistance (IR) that lead to a compensatory hyperinsulinemia due to insulin hypersecretion. The increased β-cell function is associated with increased insulin signaling that has the protein kinase B (AKT) substrate with 160 kDa (AS160) as an...

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Detalles Bibliográficos
Autores principales: Protzek, André O. P., Costa-Júnior, José M., Rezende, Luiz F., Santos, Gustavo J., Araújo, Tiago Gomes, Vettorazzi, Jean F., Ortis, Fernanda, Carneiro, Everardo M., Rafacho, Alex, Boschero, Antonio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182854/
https://www.ncbi.nlm.nih.gov/pubmed/25313308
http://dx.doi.org/10.1155/2014/983453

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