Cargando…

The Polyphenols (−)-Epigallocatechin-3-Gallate and Luteolin Synergistically Inhibit TGF-β-Induced Myofibroblast Phenotypes through RhoA and ERK Inhibition

The presence of reactive stroma, predominantly composed of myofibroblasts, is directly associated with and drives prostate cancer progression. We have previously shown that (−)-Epigallocatechin-3-gallate (EGCG), in the form of Polyphenon E, significantly decreases serum levels of HGF and VEGF in pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gray, Alana L., Stephens, Charles A., Bigelow, Rebecca L. H., Coleman, David T., Cardelli, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182889/ https://www.ncbi.nlm.nih.gov/pubmed/25272043 http://dx.doi.org/10.1371/journal.pone.0109208

Ejemplares similares

Nicorandil regulates the macrophage skewing and ameliorates myofibroblasts by inhibition of RhoA/Rho‐kinase signalling in infarcted rats
por: Lee, Tsung‐Ming, et al.
Publicado: (2017)

Green Tea Polyphenol Epigallocatechin-3-Gallate Enhance Glycogen Synthesis and Inhibit Lipogenesis in Hepatocytes
por: Kim, Jane J. Y., et al.
Publicado: (2013)

Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells
por: Chen, Rui, et al.
Publicado: (2014)

Epigallocatechin-3-Gallate, the Main Polyphenol in Green Tea, Inhibits Porcine Epidemic Diarrhea Virus In Vitro
por: Huan, Changchao, et al.
Publicado: (2021)

Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate
por: Keske, Michelle A., et al.
Publicado: (2015)

Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate
por: Patil, Pradeep R, et al.
Publicado: (2011)

Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise
por: Ahmed, Salahuddin
Publicado: (2010)

Green Tea Polyphenol Epigallocatechin-Gallate in Amyloid Aggregation and Neurodegenerative Diseases
por: Fernandes, Luiza, et al.
Publicado: (2021)

ERK1/2-HNF4α axis is involved in epigallocatechin-3-gallate inhibition of HBV replication
por: Wang, Zi-yu, et al.
Publicado: (2019)

Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats
por: Wang, Yu, et al.
Publicado: (2020)

Hyaluronidase-2 Regulates RhoA Signaling, Myofibroblast Contractility, and Other Key Profibrotic Myofibroblast Functions
por: Midgley, Adam C., et al.
Publicado: (2020)

ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis
por: Zheng, Jianzhong, et al.
Publicado: (2022)

Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea
por: Du, Guang-Jian, et al.
Publicado: (2012)

Anti-Fatigue Effect of Green Tea Polyphenols (-)-Epigallocatechin-3-Gallate (EGCG)
por: Teng, Yu-song, et al.
Publicado: (2017)

Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model
por: Qin, Sina, et al.
Publicado: (2019)

Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves’ Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways
por: Wei, Yi-Hsuan, et al.
Publicado: (2021)

Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells
por: Feng, Chenchen, et al.
Publicado: (2017)

An optogenetic tool to inhibit RhoA in Drosophila embryos
por: Guo, Hanqing, et al.
Publicado: (2023)

The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress
por: Krupkova, Olga, et al.
Publicado: (2016)

Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering and Stabilization of the Viruses
por: Reshamwala, Dhanik, et al.
Publicado: (2021)

A TRANSCRIPTIONAL CROSS–TALK BETWEEN RhoA AND c–Myc INHIBITS THE RhoA/Rock–DEPENDENT CYTOSKELETON
por: Sauzeau, Vincent, et al.
Publicado: (2010)

RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes
por: Jatho, Aline, et al.
Publicado: (2015)

Green Tea Polyphenol Epigallocatechin-3-Gallate-Stearate Inhibits the Growth of Streptococcus mutans: A Promising New Approach in Caries Prevention
por: Melok, Amy Lynn, et al.
Publicado: (2018)

Epigallocatechin gallate inhibits release of extracellular vesicles from platelets without inhibiting phosphatidylserine exposure
por: Millington-Burgess, Sarah L., et al.
Publicado: (2021)

Epigallocatechin gallate ameliorates tetrahydrochloride-induced liver toxicity in rats via inhibition of TGFβ / p-ERK/p-Smad1/2 signaling, antioxidant, anti-inflammatory activity
por: Mostafa-Hedeab, Gomaa, et al.
Publicado: (2022)

Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling
por: Jin, Heiying, et al.
Publicado: (2013)

Epigallocatechin-3-Gallate Inhibits Stem-Like Inflammatory Breast Cancer Cells
por: Mineva, Nora D., et al.
Publicado: (2013)

Epigallocatechin-3-gallate inhibits doxorubicin-induced inflammation on human ovarian tissue
por: Fabbri, R, et al.
Publicado: (2019)

Epigallocatechin Gallate Inhibits Mouse Mesenchymal Stem Cell Differentiation to Adipogenic Lineage
por: Chani, Baldeep, et al.
Publicado: (2016)

Inhibitory effects of epigallocatechin gallate and its glucoside on the human intestinal maltase inhibition
por: Nguyen, Thi Thanh Hanh, et al.
Publicado: (2012)

(−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters
por: Kawasaki, Tatsuya, et al.
Publicado: (2021)

Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions
por: Sarkar, Jaganmay, et al.
Publicado: (2022)

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate()
por: Kim, Hae-Suk, et al.
Publicado: (2014)

Inhibition of RhoA/Rho kinase pathway and smooth muscle contraction by hydrogen sulfide
por: Nalli, Ancy D., et al.
Publicado: (2017)

Polyphenol (-)-epigallocatechin gallate targeting myocardial reperfusion limits infarct size and improves cardiac function
por: Kim, Chan Jin, et al.
Publicado: (2010)

Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma
por: Menard, Caroline, et al.
Publicado: (2013)

Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate
por: Peeters, Tom H., et al.
Publicado: (2019)

The Green Tea Polyphenol Epigallocatechin-Gallate (EGCG) Interferes with Microcin E492 Amyloid Formation
por: Aguilera, Paulina, et al.
Publicado: (2023)

Combined Effects of Green Tea Extracts, Green Tea Polyphenols or Epigallocatechin Gallate with Acarbose on Inhibition against α-Amylase and α-Glucosidase in Vitro
por: Gao, Junjie, et al.
Publicado: (2013)

Epigallocatechin-3-gallate (EGCG) inhibits the migratory behavior of tumor bronchial epithelial cells
por: Hazgui, Salma, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_dmt7icuuobok9156qupo3f9j7v