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Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease

Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However,...

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Autores principales: Vo, Andrew, Hiebert, Nole M., Seergobin, Ken N., Solcz, Stephanie, Partridge, Allison, MacDonald, Penny A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183099/
https://www.ncbi.nlm.nih.gov/pubmed/25324767
http://dx.doi.org/10.3389/fnhum.2014.00784
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author Vo, Andrew
Hiebert, Nole M.
Seergobin, Ken N.
Solcz, Stephanie
Partridge, Allison
MacDonald, Penny A.
author_facet Vo, Andrew
Hiebert, Nole M.
Seergobin, Ken N.
Solcz, Stephanie
Partridge, Allison
MacDonald, Penny A.
author_sort Vo, Andrew
collection PubMed
description Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration.
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spelling pubmed-41830992014-10-16 Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease Vo, Andrew Hiebert, Nole M. Seergobin, Ken N. Solcz, Stephanie Partridge, Allison MacDonald, Penny A. Front Hum Neurosci Neuroscience Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on and/or off dopaminergic medication along with 32 healthy, age- and education-matched controls. In Session 1, participants learned to associate abstract images with specific key-press responses through trial and error via outcome feedback. In Session 2, participants provided specific responses to abstract images learned in Session 1, without feedback, precluding new feedback-based learning. By separating Sessions 1 and 2 by 24 h, we could distinguish the effect of dopaminergic medication on (a) feedback-based learning and response selection processes in Session 1 as well as on (b) response selection processes when feedback-based learning could not occur in Session 2. Accuracy achieved at the end of Session 1 were comparable across groups. PD patients on medication learned stimulus-response associations more poorly than PD patients off medication and controls. Medication did not influence decision performance in Session 2. We confirm that dopaminergic therapy impairs feedback-based learning in PD, discounting an alternative explanation that warranted consideration. Frontiers Media S.A. 2014-10-02 /pmc/articles/PMC4183099/ /pubmed/25324767 http://dx.doi.org/10.3389/fnhum.2014.00784 Text en Copyright © 2014 Vo, Hiebert, Seergobin, Solcz, Partridge and MacDonald. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Vo, Andrew
Hiebert, Nole M.
Seergobin, Ken N.
Solcz, Stephanie
Partridge, Allison
MacDonald, Penny A.
Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease
title Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease
title_full Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease
title_fullStr Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease
title_full_unstemmed Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease
title_short Dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in Parkinson's disease
title_sort dopaminergic medication impairs feedback-based stimulus-response learning but not response selection in parkinson's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183099/
https://www.ncbi.nlm.nih.gov/pubmed/25324767
http://dx.doi.org/10.3389/fnhum.2014.00784
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