Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue

Cases of delayed hemolytic anemia have been described after treatment with injectable artesunate, the current World Health Organization (WHO)–recommended first-line drug for the treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] ≥ 5 years of age) we...

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Autores principales: Burri, Christian, Ferrari, Giovanfrancesco, Ntuku, Henry Maggi, Kitoto, Antoinette Tshefu, Duparc, Stephan, Hugo, Pierre, Mitembo, Didier Kalemwa, Lengeler, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183412/
https://www.ncbi.nlm.nih.gov/pubmed/25071004
http://dx.doi.org/10.4269/ajtmh.14-0149
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author Burri, Christian
Ferrari, Giovanfrancesco
Ntuku, Henry Maggi
Kitoto, Antoinette Tshefu
Duparc, Stephan
Hugo, Pierre
Mitembo, Didier Kalemwa
Lengeler, Christian
author_facet Burri, Christian
Ferrari, Giovanfrancesco
Ntuku, Henry Maggi
Kitoto, Antoinette Tshefu
Duparc, Stephan
Hugo, Pierre
Mitembo, Didier Kalemwa
Lengeler, Christian
author_sort Burri, Christian
collection PubMed
description Cases of delayed hemolytic anemia have been described after treatment with injectable artesunate, the current World Health Organization (WHO)–recommended first-line drug for the treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] ≥ 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals and health centers of the Democratic Republic of the Congo. Complete series of hemoglobin (Hb) measurements were available for 201 patients. A decrease in Hb levels between 2 and 5 g/dL was detected in 23 (11.4%) patients during the follow-up period. For five patients, Hb levels decreased below 5 g/dL during at least one follow-up visit. All cases of delayed anemia were clinically manageable and resolved within one month.
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spelling pubmed-41834122014-10-08 Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue Burri, Christian Ferrari, Giovanfrancesco Ntuku, Henry Maggi Kitoto, Antoinette Tshefu Duparc, Stephan Hugo, Pierre Mitembo, Didier Kalemwa Lengeler, Christian Am J Trop Med Hyg Articles Cases of delayed hemolytic anemia have been described after treatment with injectable artesunate, the current World Health Organization (WHO)–recommended first-line drug for the treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] ≥ 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals and health centers of the Democratic Republic of the Congo. Complete series of hemoglobin (Hb) measurements were available for 201 patients. A decrease in Hb levels between 2 and 5 g/dL was detected in 23 (11.4%) patients during the follow-up period. For five patients, Hb levels decreased below 5 g/dL during at least one follow-up visit. All cases of delayed anemia were clinically manageable and resolved within one month. The American Society of Tropical Medicine and Hygiene 2014-10-01 /pmc/articles/PMC4183412/ /pubmed/25071004 http://dx.doi.org/10.4269/ajtmh.14-0149 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Burri, Christian
Ferrari, Giovanfrancesco
Ntuku, Henry Maggi
Kitoto, Antoinette Tshefu
Duparc, Stephan
Hugo, Pierre
Mitembo, Didier Kalemwa
Lengeler, Christian
Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue
title Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue
title_full Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue
title_fullStr Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue
title_full_unstemmed Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue
title_short Delayed Anemia after Treatment with Injectable Artesunate in the Democratic Republic of the Congo: A Manageable Issue
title_sort delayed anemia after treatment with injectable artesunate in the democratic republic of the congo: a manageable issue
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183412/
https://www.ncbi.nlm.nih.gov/pubmed/25071004
http://dx.doi.org/10.4269/ajtmh.14-0149
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