Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine

[Image: see text] Described here are mechanistic details of the chemical reactivities of two modified/saturated pyrimidine residues that represent naturally occurring forms of DNA damage: 5-thyminyl-5,6-dihydrothymine, commonly referred to as the “spore photoproduct” (SP), and 5,6-dihydro-2′-deoxyur...

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Detalles Bibliográficos
Autores principales: Lin, Gengjie, Jian, Yajun, Dria, Karl J., Long, Eric C., Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183628/
https://www.ncbi.nlm.nih.gov/pubmed/25127075
http://dx.doi.org/10.1021/ja505407p

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