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Preferential potentiation of topoisomerase I poison cytotoxicity by PARP inhibition in S phase
BACKGROUND: Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S...
Autores principales: | Znojek, P, Willmore, E, Curtin, N J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183837/ https://www.ncbi.nlm.nih.gov/pubmed/25003660 http://dx.doi.org/10.1038/bjc.2014.378 |
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