PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients

BACKGROUND: The blockade of PD-1–PD-L1 pathway is emerging as an effective therapeutic strategy for several advanced cancers. But the immune regulatory role of PD-1–PD-L1 pathway is not clear in colorectal cancer (CRC) patients. This study aims to evaluate the role of PD-1–PD-L1 pathway in CD8(+) T-...

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Detalles Bibliográficos
Autores principales: Wu, X, Zhang, H, Xing, Q, Cui, J, Li, J, Li, Y, Tan, Y, Wang, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183848/
https://www.ncbi.nlm.nih.gov/pubmed/25093496
http://dx.doi.org/10.1038/bjc.2014.416

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