The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records

BACKGROUND: The risk of cancer with hypercalcaemia in primary care is unknown. METHODS: This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified. RESULTS: Participants (54 267) had calciu...

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Detalles Bibliográficos
Autores principales: Hamilton, F, Carroll, R, Hamilton, W, Salisbury, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183854/
https://www.ncbi.nlm.nih.gov/pubmed/25093495
http://dx.doi.org/10.1038/bjc.2014.433
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author Hamilton, F
Carroll, R
Hamilton, W
Salisbury, C
author_facet Hamilton, F
Carroll, R
Hamilton, W
Salisbury, C
author_sort Hamilton, F
collection PubMed
description BACKGROUND: The risk of cancer with hypercalcaemia in primary care is unknown. METHODS: This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified. RESULTS: Participants (54 267) had calcium results: 1674 (3%) were ⩾2.6 mmol l(−1). Hypercalcaemia was strongly associated with cancer, especially in males: OR 2.92, 95% CI 2.17–3.93, P=<0.001; positive predictive value (PPV) 11.5% females: OR 1.86, 95% CI 1.39–2.50, P<0.001: PPV 4.1%. CONCLUSIONS: Hypercalcaemia is strongly associated with cancer in primary care, with men at most risk, despite hypercalcaemia being more common in women.
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spelling pubmed-41838542015-09-23 The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records Hamilton, F Carroll, R Hamilton, W Salisbury, C Br J Cancer Epidemiology BACKGROUND: The risk of cancer with hypercalcaemia in primary care is unknown. METHODS: This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified. RESULTS: Participants (54 267) had calcium results: 1674 (3%) were ⩾2.6 mmol l(−1). Hypercalcaemia was strongly associated with cancer, especially in males: OR 2.92, 95% CI 2.17–3.93, P=<0.001; positive predictive value (PPV) 11.5% females: OR 1.86, 95% CI 1.39–2.50, P<0.001: PPV 4.1%. CONCLUSIONS: Hypercalcaemia is strongly associated with cancer in primary care, with men at most risk, despite hypercalcaemia being more common in women. Nature Publishing Group 2014-09-23 2014-08-05 /pmc/articles/PMC4183854/ /pubmed/25093495 http://dx.doi.org/10.1038/bjc.2014.433 Text en Copyright © 2014 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Hamilton, F
Carroll, R
Hamilton, W
Salisbury, C
The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
title The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
title_full The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
title_fullStr The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
title_full_unstemmed The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
title_short The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
title_sort risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183854/
https://www.ncbi.nlm.nih.gov/pubmed/25093495
http://dx.doi.org/10.1038/bjc.2014.433
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