Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A

Filamins regulate cell locomotion and associate with diverse signaling molecules. We have recently found that targeting filamin A (FLNA) reduces RAS-induced lung adenocarcinomas. In this study, we explored the role of another major filamin isoform, filamin B (FLNB), in tumor development. In contrast...

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Detalles Bibliográficos
Autores principales: Bandaru, S, Zhou, A-X, Rouhi, P, Zhang, Y, Bergo, M O, Cao, Y, Akyürek, L M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183982/
https://www.ncbi.nlm.nih.gov/pubmed/25244493
http://dx.doi.org/10.1038/oncsis.2014.33

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