A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics

Here we reported the first fluorescent probe with aggregation-induced emission characteristics, namely AIE-S, for the detection of hydrogen sulfide (H(2)S) in live cells. The detection system is selective for complicated biological application and the response is fast enough to complete within secon...

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Detalles Bibliográficos
Autores principales: Li, Xin, Yang, Chengyu, Wu, Kai, Hu, Yongzhou, Han, Yifeng, Liang, Steven H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184000/
https://www.ncbi.nlm.nih.gov/pubmed/25285171
http://dx.doi.org/10.7150/thno.10330
Descripción
Sumario:Here we reported the first fluorescent probe with aggregation-induced emission characteristics, namely AIE-S, for the detection of hydrogen sulfide (H(2)S) in live cells. The detection system is selective for complicated biological application and the response is fast enough to complete within seconds. Moreover, the probe exhibits the unique advantage of being immune to aggregation-caused quenching which is a detrimental phenomenon limiting the application of most current available H(2)S fluorescent probes. The detection mechanism was investigated and postulated to be S(2-) initiated de-coordination and thereafter aggregation of the AIE-S complex.

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