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Serum vitamin c and iron levels in oral submucous fibrosis

BACKGROUND: In this study Serum Vitamin C and Iron levels in Oral submucous fibrosis (OSMF) were estimated. The objective was to evaluate the correlation between Serum Vitamin C and Iron levels in OSMF individuals. Serum Iron content can be a predictor for the progression of this condition. OSMF is...

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Autores principales: Guruprasad, R, Nair, Preeti P, Singh, Manika, Singh, Manishi, Singh, MP, Jain, Arpit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184322/
https://www.ncbi.nlm.nih.gov/pubmed/25565730
http://dx.doi.org/10.4103/0975-962X.135266
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author Guruprasad, R
Nair, Preeti P
Singh, Manika
Singh, Manishi
Singh, MP
Jain, Arpit
author_facet Guruprasad, R
Nair, Preeti P
Singh, Manika
Singh, Manishi
Singh, MP
Jain, Arpit
author_sort Guruprasad, R
collection PubMed
description BACKGROUND: In this study Serum Vitamin C and Iron levels in Oral submucous fibrosis (OSMF) were estimated. The objective was to evaluate the correlation between Serum Vitamin C and Iron levels in OSMF individuals. Serum Iron content can be a predictor for the progression of this condition. OSMF is basically a disorder of collagen metabolism where Vitamin C gets utilized in conversion of proline into hydroxyproline, this hydroxylation reaction requires ferrous Iron and Vitamin C. Many studies regarding micronutrients and other antioxidants levels have been emphasized, but very few studies are done on the Serum levels of Vitamin C and its correlation with Iron in OSMF patients. METHODS: Thirty five OSMF patients and 50 deleterious habit free healthy individuals (controls) were selected. Two ml of venous blood was collected from each individual. Vitamin C level in serum was estimated by 2-4 dinitrophenylhydrazine method and Iron estimated by Tripyridyl method. RESULTS: The level of Serum Vitamin-C and Iron was significantly decreased in OSMF patients when compared to controls which were statistically significant. CONCLUSION: On the basis of these observations, it seems possible that the chemical, thermal and/or mechanical factors associated with the use of areca nut may act in conjunction with the Vitamin C and Iron deficiency leading to the development of OSMF. Therapeutic substitution of vitamin C and Iron may be recommended in the management of OSMF
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spelling pubmed-41843222014-11-17 Serum vitamin c and iron levels in oral submucous fibrosis Guruprasad, R Nair, Preeti P Singh, Manika Singh, Manishi Singh, MP Jain, Arpit Indian J Dent Original Article BACKGROUND: In this study Serum Vitamin C and Iron levels in Oral submucous fibrosis (OSMF) were estimated. The objective was to evaluate the correlation between Serum Vitamin C and Iron levels in OSMF individuals. Serum Iron content can be a predictor for the progression of this condition. OSMF is basically a disorder of collagen metabolism where Vitamin C gets utilized in conversion of proline into hydroxyproline, this hydroxylation reaction requires ferrous Iron and Vitamin C. Many studies regarding micronutrients and other antioxidants levels have been emphasized, but very few studies are done on the Serum levels of Vitamin C and its correlation with Iron in OSMF patients. METHODS: Thirty five OSMF patients and 50 deleterious habit free healthy individuals (controls) were selected. Two ml of venous blood was collected from each individual. Vitamin C level in serum was estimated by 2-4 dinitrophenylhydrazine method and Iron estimated by Tripyridyl method. RESULTS: The level of Serum Vitamin-C and Iron was significantly decreased in OSMF patients when compared to controls which were statistically significant. CONCLUSION: On the basis of these observations, it seems possible that the chemical, thermal and/or mechanical factors associated with the use of areca nut may act in conjunction with the Vitamin C and Iron deficiency leading to the development of OSMF. Therapeutic substitution of vitamin C and Iron may be recommended in the management of OSMF Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4184322/ /pubmed/25565730 http://dx.doi.org/10.4103/0975-962X.135266 Text en Copyright: © Indian Journal of Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Guruprasad, R
Nair, Preeti P
Singh, Manika
Singh, Manishi
Singh, MP
Jain, Arpit
Serum vitamin c and iron levels in oral submucous fibrosis
title Serum vitamin c and iron levels in oral submucous fibrosis
title_full Serum vitamin c and iron levels in oral submucous fibrosis
title_fullStr Serum vitamin c and iron levels in oral submucous fibrosis
title_full_unstemmed Serum vitamin c and iron levels in oral submucous fibrosis
title_short Serum vitamin c and iron levels in oral submucous fibrosis
title_sort serum vitamin c and iron levels in oral submucous fibrosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184322/
https://www.ncbi.nlm.nih.gov/pubmed/25565730
http://dx.doi.org/10.4103/0975-962X.135266
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