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Serum vitamin c and iron levels in oral submucous fibrosis
BACKGROUND: In this study Serum Vitamin C and Iron levels in Oral submucous fibrosis (OSMF) were estimated. The objective was to evaluate the correlation between Serum Vitamin C and Iron levels in OSMF individuals. Serum Iron content can be a predictor for the progression of this condition. OSMF is...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184322/ https://www.ncbi.nlm.nih.gov/pubmed/25565730 http://dx.doi.org/10.4103/0975-962X.135266 |
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author | Guruprasad, R Nair, Preeti P Singh, Manika Singh, Manishi Singh, MP Jain, Arpit |
author_facet | Guruprasad, R Nair, Preeti P Singh, Manika Singh, Manishi Singh, MP Jain, Arpit |
author_sort | Guruprasad, R |
collection | PubMed |
description | BACKGROUND: In this study Serum Vitamin C and Iron levels in Oral submucous fibrosis (OSMF) were estimated. The objective was to evaluate the correlation between Serum Vitamin C and Iron levels in OSMF individuals. Serum Iron content can be a predictor for the progression of this condition. OSMF is basically a disorder of collagen metabolism where Vitamin C gets utilized in conversion of proline into hydroxyproline, this hydroxylation reaction requires ferrous Iron and Vitamin C. Many studies regarding micronutrients and other antioxidants levels have been emphasized, but very few studies are done on the Serum levels of Vitamin C and its correlation with Iron in OSMF patients. METHODS: Thirty five OSMF patients and 50 deleterious habit free healthy individuals (controls) were selected. Two ml of venous blood was collected from each individual. Vitamin C level in serum was estimated by 2-4 dinitrophenylhydrazine method and Iron estimated by Tripyridyl method. RESULTS: The level of Serum Vitamin-C and Iron was significantly decreased in OSMF patients when compared to controls which were statistically significant. CONCLUSION: On the basis of these observations, it seems possible that the chemical, thermal and/or mechanical factors associated with the use of areca nut may act in conjunction with the Vitamin C and Iron deficiency leading to the development of OSMF. Therapeutic substitution of vitamin C and Iron may be recommended in the management of OSMF |
format | Online Article Text |
id | pubmed-4184322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41843222014-11-17 Serum vitamin c and iron levels in oral submucous fibrosis Guruprasad, R Nair, Preeti P Singh, Manika Singh, Manishi Singh, MP Jain, Arpit Indian J Dent Original Article BACKGROUND: In this study Serum Vitamin C and Iron levels in Oral submucous fibrosis (OSMF) were estimated. The objective was to evaluate the correlation between Serum Vitamin C and Iron levels in OSMF individuals. Serum Iron content can be a predictor for the progression of this condition. OSMF is basically a disorder of collagen metabolism where Vitamin C gets utilized in conversion of proline into hydroxyproline, this hydroxylation reaction requires ferrous Iron and Vitamin C. Many studies regarding micronutrients and other antioxidants levels have been emphasized, but very few studies are done on the Serum levels of Vitamin C and its correlation with Iron in OSMF patients. METHODS: Thirty five OSMF patients and 50 deleterious habit free healthy individuals (controls) were selected. Two ml of venous blood was collected from each individual. Vitamin C level in serum was estimated by 2-4 dinitrophenylhydrazine method and Iron estimated by Tripyridyl method. RESULTS: The level of Serum Vitamin-C and Iron was significantly decreased in OSMF patients when compared to controls which were statistically significant. CONCLUSION: On the basis of these observations, it seems possible that the chemical, thermal and/or mechanical factors associated with the use of areca nut may act in conjunction with the Vitamin C and Iron deficiency leading to the development of OSMF. Therapeutic substitution of vitamin C and Iron may be recommended in the management of OSMF Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4184322/ /pubmed/25565730 http://dx.doi.org/10.4103/0975-962X.135266 Text en Copyright: © Indian Journal of Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Guruprasad, R Nair, Preeti P Singh, Manika Singh, Manishi Singh, MP Jain, Arpit Serum vitamin c and iron levels in oral submucous fibrosis |
title | Serum vitamin c and iron levels in oral submucous fibrosis |
title_full | Serum vitamin c and iron levels in oral submucous fibrosis |
title_fullStr | Serum vitamin c and iron levels in oral submucous fibrosis |
title_full_unstemmed | Serum vitamin c and iron levels in oral submucous fibrosis |
title_short | Serum vitamin c and iron levels in oral submucous fibrosis |
title_sort | serum vitamin c and iron levels in oral submucous fibrosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184322/ https://www.ncbi.nlm.nih.gov/pubmed/25565730 http://dx.doi.org/10.4103/0975-962X.135266 |
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