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Total Synthesis of (+)-18-epi-Latrunculol A: Development of a Synthetic Route
[Image: see text] The evolution of an enantioselective total synthesis of (+)-18-epi-latrunculol A, a congener of the marine-sponge-derived latrunculins A and B, is reported. Key steps include a late-stage Mitsunobu macrolactonization to construct the 16-membered macrolactone, a mild Carreira alkyny...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184459/ https://www.ncbi.nlm.nih.gov/pubmed/25243951 http://dx.doi.org/10.1021/jo501733m |