Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation

KEY CLINICAL MESSAGE: Neurotoxic snake envenomation can result in respiratory failure and death. Early treatment is considered important to survival. Inexpensive, heat-stable, needle-free, antiparalytics could facilitate early treatment of snakebite and save lives, but none have been developed. An e...

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Detalles Bibliográficos
Autores principales: Lewin, Matthew R, Bickler, Philip, Heier, Tom, Feiner, John, Montauk, Lance, Mensh, Brett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184533/
https://www.ncbi.nlm.nih.gov/pubmed/25356201
http://dx.doi.org/10.1002/ccr3.3
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author Lewin, Matthew R
Bickler, Philip
Heier, Tom
Feiner, John
Montauk, Lance
Mensh, Brett
author_facet Lewin, Matthew R
Bickler, Philip
Heier, Tom
Feiner, John
Montauk, Lance
Mensh, Brett
author_sort Lewin, Matthew R
collection PubMed
description KEY CLINICAL MESSAGE: Neurotoxic snake envenomation can result in respiratory failure and death. Early treatment is considered important to survival. Inexpensive, heat-stable, needle-free, antiparalytics could facilitate early treatment of snakebite and save lives, but none have been developed. An experiment using aerosolized neostigmine to reverse paralysis suggests how early interventions could be developed.
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spelling pubmed-41845332014-10-29 Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation Lewin, Matthew R Bickler, Philip Heier, Tom Feiner, John Montauk, Lance Mensh, Brett Clin Case Rep Case Reports KEY CLINICAL MESSAGE: Neurotoxic snake envenomation can result in respiratory failure and death. Early treatment is considered important to survival. Inexpensive, heat-stable, needle-free, antiparalytics could facilitate early treatment of snakebite and save lives, but none have been developed. An experiment using aerosolized neostigmine to reverse paralysis suggests how early interventions could be developed. Blackwell Publishing Ltd 2013-10 2013-07-24 /pmc/articles/PMC4184533/ /pubmed/25356201 http://dx.doi.org/10.1002/ccr3.3 Text en © 2013 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Lewin, Matthew R
Bickler, Philip
Heier, Tom
Feiner, John
Montauk, Lance
Mensh, Brett
Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
title Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
title_full Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
title_fullStr Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
title_full_unstemmed Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
title_short Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
title_sort reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184533/
https://www.ncbi.nlm.nih.gov/pubmed/25356201
http://dx.doi.org/10.1002/ccr3.3
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