Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes

Uridine 5′-diphosphate-glucuronosyltransferases (UGTs) are phase II drug-metabolizing enzymes that catalyze glucuronidation of various endogenous and exogenous substrates. Among 19 functional human UGTs, UGT1A family enzymes largely contribute to the metabolism of clinically used drugs. While the UG...

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Detalles Bibliográficos
Autores principales: Kutsuno, Yuki, Sumida, Kyohei, Itoh, Tomoo, Tukey, Robert H, Fujiwara, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184567/
https://www.ncbi.nlm.nih.gov/pubmed/25505556
http://dx.doi.org/10.1002/prp2.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184567/
https://www.ncbi.nlm.nih.gov/pubmed/25505556
http://dx.doi.org/10.1002/prp2.2

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