Cargando…
Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study
The epidemiology of Clostridium difficile infection (CDI) has changed over time and between countries. It is therefore essential to monitor the characteristics of patients at risk of infection and the circulating strains to recognize local and global trends, and improve patient management. From Dece...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184660/ https://www.ncbi.nlm.nih.gov/pubmed/25356346 http://dx.doi.org/10.1002/nmi2.43 |
_version_ | 1782337887240454144 |
---|---|
author | Foster, N F Collins, D A Ditchburn, S L Duncan, C N van Schalkwyk, J W Golledge, C L Keed, A B R Riley, T V |
author_facet | Foster, N F Collins, D A Ditchburn, S L Duncan, C N van Schalkwyk, J W Golledge, C L Keed, A B R Riley, T V |
author_sort | Foster, N F |
collection | PubMed |
description | The epidemiology of Clostridium difficile infection (CDI) has changed over time and between countries. It is therefore essential to monitor the characteristics of patients at risk of infection and the circulating strains to recognize local and global trends, and improve patient management. From December 2011 to May 2012 we conducted a prospective, observational epidemiological study of patients with laboratory-confirmed CDI at two tertiary teaching hospitals in Perth, Western Australia to determine CDI incidence and risk factors in an Australian setting. The incidence of CDI varied from 5.2 to 8.1 cases/10 000 occupied bed days (OBDs) at one hospital and from 3.9 to 16.3/10 000 OBDs at the second hospital. In total, 80 patients with laboratory-confirmed CDI met eligibility criteria and consented to be in the study. More than half (53.8%) had hospital-onset disease, 28.8% had community-onset and healthcare facility-associated disease and 7.5% were community-associated infections according to the definitions used. Severe CDI was observed in 40.0% of these cases but the 30-day mortality rate for all cases was only 2.5%. Besides a shorter length of stay among cases of community-onset CDI, no characteristics were identified that were significantly associated with community-onset or severe CDI. From 70 isolates, 34 different ribotypes were identified. The predominant ribotypes were 014 (24.3%), 020 (5.7%), 056 (5.7%) and 070 (5.7%). Whereas this study suggests that the characteristics of CDI cases in Australia are not markedly different from those in other developed countries, the increase in CDI rate observed emphasizes the importance of surveillance. |
format | Online Article Text |
id | pubmed-4184660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41846602014-10-29 Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study Foster, N F Collins, D A Ditchburn, S L Duncan, C N van Schalkwyk, J W Golledge, C L Keed, A B R Riley, T V New Microbes New Infect Original Articles The epidemiology of Clostridium difficile infection (CDI) has changed over time and between countries. It is therefore essential to monitor the characteristics of patients at risk of infection and the circulating strains to recognize local and global trends, and improve patient management. From December 2011 to May 2012 we conducted a prospective, observational epidemiological study of patients with laboratory-confirmed CDI at two tertiary teaching hospitals in Perth, Western Australia to determine CDI incidence and risk factors in an Australian setting. The incidence of CDI varied from 5.2 to 8.1 cases/10 000 occupied bed days (OBDs) at one hospital and from 3.9 to 16.3/10 000 OBDs at the second hospital. In total, 80 patients with laboratory-confirmed CDI met eligibility criteria and consented to be in the study. More than half (53.8%) had hospital-onset disease, 28.8% had community-onset and healthcare facility-associated disease and 7.5% were community-associated infections according to the definitions used. Severe CDI was observed in 40.0% of these cases but the 30-day mortality rate for all cases was only 2.5%. Besides a shorter length of stay among cases of community-onset CDI, no characteristics were identified that were significantly associated with community-onset or severe CDI. From 70 isolates, 34 different ribotypes were identified. The predominant ribotypes were 014 (24.3%), 020 (5.7%), 056 (5.7%) and 070 (5.7%). Whereas this study suggests that the characteristics of CDI cases in Australia are not markedly different from those in other developed countries, the increase in CDI rate observed emphasizes the importance of surveillance. BlackWell Publishing Ltd 2014-05 2014-04-01 /pmc/articles/PMC4184660/ /pubmed/25356346 http://dx.doi.org/10.1002/nmi2.43 Text en © 2014 The Authors. New Microbes and New Infections published by John Wiley & Sons Ltd on behalf of the European Society of Clinical Microbiology and Infectious Disease. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Foster, N F Collins, D A Ditchburn, S L Duncan, C N van Schalkwyk, J W Golledge, C L Keed, A B R Riley, T V Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study |
title | Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study |
title_full | Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study |
title_fullStr | Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study |
title_full_unstemmed | Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study |
title_short | Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study |
title_sort | epidemiology of clostridium difficile infection in two tertiary-care hospitals in perth, western australia: a cross-sectional study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184660/ https://www.ncbi.nlm.nih.gov/pubmed/25356346 http://dx.doi.org/10.1002/nmi2.43 |
work_keys_str_mv | AT fosternf epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT collinsda epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT ditchburnsl epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT duncancn epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT vanschalkwykjw epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT golledgecl epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT keedabr epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy AT rileytv epidemiologyofclostridiumdifficileinfectionintwotertiarycarehospitalsinperthwesternaustraliaacrosssectionalstudy |