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A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin
INTRODUCTION: Diabetes mellitus (DM) is a multiorgan disease that leads to neurovascular complications that disturb the normal erectile function. AIM: The aim of the current work was to study the early changes occurring in the level of calcitonin gene-related peptide (CGRP) and histopathological cha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184714/ https://www.ncbi.nlm.nih.gov/pubmed/25356283 http://dx.doi.org/10.1002/sm2.3 |
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author | El-Kamshoushi, Abdel Aal M Abdallah, Wafaa I Helal, Suzan F El Azhary, Nesrine M Hassan, Eman M |
author_facet | El-Kamshoushi, Abdel Aal M Abdallah, Wafaa I Helal, Suzan F El Azhary, Nesrine M Hassan, Eman M |
author_sort | El-Kamshoushi, Abdel Aal M |
collection | PubMed |
description | INTRODUCTION: Diabetes mellitus (DM) is a multiorgan disease that leads to neurovascular complications that disturb the normal erectile function. AIM: The aim of the current work was to study the early changes occurring in the level of calcitonin gene-related peptide (CGRP) and histopathological changes in penile tissues of uncontrolled diabetic rats. MATERIALS AND METHODS: This study was carried on 50 adult male Sprague-Dawley rats divided into two main groups: group I (control, n = 10) and group II (diabetic, n = 40). Type I DM was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). The tissue level of CGRP and histopathological examination of rat penises were assessed at 2, 4, 6, and 8 weeks after induction of DM. RESULTS: CGRP was higher in the diabetic group at 4, 6, and 8 weeks than in the control group. However, endothelial changes and decreased smooth muscles mass started only 2 weeks after induction of DM. CONCLUSION: Deterioration of histopathological features of the uncontrolled diabetic rats corporeal tissues is time dependent. Furthermore, vascular changes seem to precede the neurological changes. El-Kamshoushi AAM, Abdallah WI, Helal SF, El Azhary NM, and Hassan EM. A study of the early changes of the level of calcitonin gene-related peptide and histopathology of penises of rats with experimentally induced type I diabetes mellitus by streptozocin. Sex Med 2013;1:21–29. |
format | Online Article Text |
id | pubmed-4184714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41847142014-10-29 A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin El-Kamshoushi, Abdel Aal M Abdallah, Wafaa I Helal, Suzan F El Azhary, Nesrine M Hassan, Eman M Sex Med Original Research—Erectile Dysfunction INTRODUCTION: Diabetes mellitus (DM) is a multiorgan disease that leads to neurovascular complications that disturb the normal erectile function. AIM: The aim of the current work was to study the early changes occurring in the level of calcitonin gene-related peptide (CGRP) and histopathological changes in penile tissues of uncontrolled diabetic rats. MATERIALS AND METHODS: This study was carried on 50 adult male Sprague-Dawley rats divided into two main groups: group I (control, n = 10) and group II (diabetic, n = 40). Type I DM was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). The tissue level of CGRP and histopathological examination of rat penises were assessed at 2, 4, 6, and 8 weeks after induction of DM. RESULTS: CGRP was higher in the diabetic group at 4, 6, and 8 weeks than in the control group. However, endothelial changes and decreased smooth muscles mass started only 2 weeks after induction of DM. CONCLUSION: Deterioration of histopathological features of the uncontrolled diabetic rats corporeal tissues is time dependent. Furthermore, vascular changes seem to precede the neurological changes. El-Kamshoushi AAM, Abdallah WI, Helal SF, El Azhary NM, and Hassan EM. A study of the early changes of the level of calcitonin gene-related peptide and histopathology of penises of rats with experimentally induced type I diabetes mellitus by streptozocin. Sex Med 2013;1:21–29. Blackwell Publishing Ltd 2013-08 2013-07-23 /pmc/articles/PMC4184714/ /pubmed/25356283 http://dx.doi.org/10.1002/sm2.3 Text en © 2013 The Authors. Sexual Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Sexual Medicine. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research—Erectile Dysfunction El-Kamshoushi, Abdel Aal M Abdallah, Wafaa I Helal, Suzan F El Azhary, Nesrine M Hassan, Eman M A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin |
title | A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin |
title_full | A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin |
title_fullStr | A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin |
title_full_unstemmed | A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin |
title_short | A Study of the Early Changes of the Level of Calcitonin Gene-Related Peptide and Histopathology of Penises of Rats with Experimentally Induced Type I Diabetes Mellitus by Streptozocin |
title_sort | study of the early changes of the level of calcitonin gene-related peptide and histopathology of penises of rats with experimentally induced type i diabetes mellitus by streptozocin |
topic | Original Research—Erectile Dysfunction |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184714/ https://www.ncbi.nlm.nih.gov/pubmed/25356283 http://dx.doi.org/10.1002/sm2.3 |
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