Altered cortical thickness following prenatal sodium valproate exposure

Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an assoc...

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Autores principales: Wood, Amanda G, Chen, Jian, Barton, Sarah, Nadebaum, Caroline, Anderson, Vicki A, Catroppa, Cathy, Reutens, David C, O'Brien, Terence J, Vajda, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184779/
https://www.ncbi.nlm.nih.gov/pubmed/25356420
http://dx.doi.org/10.1002/acn3.74
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author Wood, Amanda G
Chen, Jian
Barton, Sarah
Nadebaum, Caroline
Anderson, Vicki A
Catroppa, Cathy
Reutens, David C
O'Brien, Terence J
Vajda, Frank
author_facet Wood, Amanda G
Chen, Jian
Barton, Sarah
Nadebaum, Caroline
Anderson, Vicki A
Catroppa, Cathy
Reutens, David C
O'Brien, Terence J
Vajda, Frank
author_sort Wood, Amanda G
collection PubMed
description Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.
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spelling pubmed-41847792014-10-29 Altered cortical thickness following prenatal sodium valproate exposure Wood, Amanda G Chen, Jian Barton, Sarah Nadebaum, Caroline Anderson, Vicki A Catroppa, Cathy Reutens, David C O'Brien, Terence J Vajda, Frank Ann Clin Transl Neurol Brief Communications Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children. BlackWell Publishing Ltd 2014-07 2014-07-03 /pmc/articles/PMC4184779/ /pubmed/25356420 http://dx.doi.org/10.1002/acn3.74 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Wood, Amanda G
Chen, Jian
Barton, Sarah
Nadebaum, Caroline
Anderson, Vicki A
Catroppa, Cathy
Reutens, David C
O'Brien, Terence J
Vajda, Frank
Altered cortical thickness following prenatal sodium valproate exposure
title Altered cortical thickness following prenatal sodium valproate exposure
title_full Altered cortical thickness following prenatal sodium valproate exposure
title_fullStr Altered cortical thickness following prenatal sodium valproate exposure
title_full_unstemmed Altered cortical thickness following prenatal sodium valproate exposure
title_short Altered cortical thickness following prenatal sodium valproate exposure
title_sort altered cortical thickness following prenatal sodium valproate exposure
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184779/
https://www.ncbi.nlm.nih.gov/pubmed/25356420
http://dx.doi.org/10.1002/acn3.74
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