Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study

BACKGROUND: Cardiomyocytes located at the ischemic border zone of infarcted ventricle are accompanied by redistribution of gap junctions, which mediate electrical transmission between cardiomyocytes. This ischemic border zone provides an arrhythmogenic substrate. It was also shown that sodium (Na(+)...

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Detalles Bibliográficos
Autores principales: Tsumoto, Kunichika, Ashihara, Takashi, Haraguchi, Ryo, Nakazawa, Kazuo, Kurachi, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184874/
https://www.ncbi.nlm.nih.gov/pubmed/25279776
http://dx.doi.org/10.1371/journal.pone.0109271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184874/
https://www.ncbi.nlm.nih.gov/pubmed/25279776
http://dx.doi.org/10.1371/journal.pone.0109271

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