Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules

We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices...

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Detalles Bibliográficos
Autores principales: Wang, Baojun, Buck, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185417/
https://www.ncbi.nlm.nih.gov/pubmed/25062273
http://dx.doi.org/10.1039/c4cc05264a
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author Wang, Baojun
Buck, Martin
author_facet Wang, Baojun
Buck, Martin
author_sort Wang, Baojun
collection PubMed
description We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity.
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spelling pubmed-41854172014-12-11 Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules Wang, Baojun Buck, Martin Chem Commun (Camb) Chemistry We designed and constructed versatile modular genetic logic gates in bacterial cells. These function as digital logic 1-input Buffer gate, 2-input and 3-input AND gates with one inverted input and integrate multiple chemical input signals in customised logic manners. Such rapidly engineered devices serve to achieve increased sensing signal selectivity. Royal Society of Chemistry 2014-10-11 2014-07-25 /pmc/articles/PMC4185417/ /pubmed/25062273 http://dx.doi.org/10.1039/c4cc05264a Text en This journal is © The Royal Society of Chemistry 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Wang, Baojun
Buck, Martin
Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
title Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
title_full Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
title_fullStr Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
title_full_unstemmed Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
title_short Rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
title_sort rapid engineering of versatile molecular logic gates using heterologous genetic transcriptional modules
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185417/
https://www.ncbi.nlm.nih.gov/pubmed/25062273
http://dx.doi.org/10.1039/c4cc05264a
work_keys_str_mv AT wangbaojun rapidengineeringofversatilemolecularlogicgatesusingheterologousgenetictranscriptionalmodules
AT buckmartin rapidengineeringofversatilemolecularlogicgatesusingheterologousgenetictranscriptionalmodules

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