Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drug

The in vitro metabolism of dronedarone and its major metabolites has been studied in human liver microsomes and cryopreserved hepatocytes in primary culture through the use of specific or total cytochrome P450 (CYP) and monoamine oxidase (MAO) inhibitors. The identification of the main metabolites a...

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Detalles Bibliográficos
Autores principales: Klieber, Sylvie, Arabeyre-Fabre, Catherine, Moliner, Patricia, Marti, Eric, Mandray, Martine, Ngo, Robert, Ollier, Céline, Brun, Priscilla, Fabre, Gérard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186413/
https://www.ncbi.nlm.nih.gov/pubmed/25505590
http://dx.doi.org/10.1002/prp2.44

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