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Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition

According to the “amyloid hypothesis,” accumulation of amyloid beta (Aβ) peptides in the brain is linked to the development of Alzheimer's disease. The aims of this investigation were to develop a model for the age-dependent amyloid accumulation and to quantify the age- and treatment-duration-d...

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Detalles Bibliográficos
Autores principales:	Parkinson, Joanna, Ploeger, Bart, Appelkvist, Paulina, Bogstedt, Anna, Dillner Bergstedt, Karin, Eketjäll, Susanna, Visser, Sandra A G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186430/ https://www.ncbi.nlm.nih.gov/pubmed/25505567 http://dx.doi.org/10.1002/prp2.12

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