Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis

BACKGROUND: Selective disruption of the spleen tyrosine kinase (Syk) represents a novel strategy to control B-cell functional responses by inhibition of B-cell antigen receptor (BCR) signaling. PRT062607 (P505-15) is a highly selective small molecule Syk inhibitor that potently suppresses B-cell fun...

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Detalles Bibliográficos
Autores principales: Coffey, Greg, Betz, Andreas, Graf, Jonathan, Stephens, Gillian, Hua Lin, Pei, Imboden, John, Sinha, Uma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186432/
https://www.ncbi.nlm.nih.gov/pubmed/25505569
http://dx.doi.org/10.1002/prp2.16

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