The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β(2)-adrenoceptor agonist in preclinical animal species

Bronchodilators are a central therapy for symptom relief in respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma, with inhaled β(2)-adrenoceptor agonists and anticholinergics being the primary treatments available. The present studies evaluated the in vivo pharmacolog...

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Detalles Bibliográficos
Autores principales: Salmon, Michael, Tannheimer, Stacey L, Gentzler, Terry T, Cui, Zhi-Hua, Sorensen, Eric A, Hartsough, Kimberly C, Kim, Musong, Purvis, Lafe J, Barrett, Edward G, McDonald, Jacob D, Rudolph, Karin, Doyle-Eisele, Melanie, Kuehl, Philip J, Royer, Christopher M, Baker, William R, Phillips, Gary B, Wright, Clifford D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186437/
https://www.ncbi.nlm.nih.gov/pubmed/25505595
http://dx.doi.org/10.1002/prp2.46

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