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PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways

The enzyme phosphodiesterase 10A (PDE10A) regulates the activity of striatal, medium spiny neurons (MSNs), which are divided into a behaviorally stimulating, Gs-coupled D(1) receptor-expressing “direct” pathway and a behaviorally suppressant, Gi-coupled D(2) receptor-expressing “indirect” pathway. A...

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Detalles Bibliográficos
Autores principales:	Megens, Anton A H P, Hendrickx, Herman M R, Mahieu, Michel M A, Wellens, Annemie L Y, de Boer, Peter, Vanhoof, Greet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186443/ https://www.ncbi.nlm.nih.gov/pubmed/25505601 http://dx.doi.org/10.1002/prp2.57

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