Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol

Morphine is still the mainstay in treatment of severe pain and is metabolized in the liver mainly by glucuronidation, partly to the pharmacologically active morphine-6-glucuronide (M6G). The sulfation pathway has attracted much less attention but may also form active metabolites. The aim of the pres...

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Detalles Bibliográficos
Autores principales: Andersson, Maria, Björkhem-Bergman, Linda, Ekström, Lena, Bergqvist, Lena, Lagercrantz, Hugo, Rane, Anders, Beck, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186450/
https://www.ncbi.nlm.nih.gov/pubmed/25505615
http://dx.doi.org/10.1002/prp2.71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186450/
https://www.ncbi.nlm.nih.gov/pubmed/25505615
http://dx.doi.org/10.1002/prp2.71

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