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Detection of morphine-3-sulfate and morphine-6-sulfate in human urine and plasma, and formation in liver cytosol
Morphine is still the mainstay in treatment of severe pain and is metabolized in the liver mainly by glucuronidation, partly to the pharmacologically active morphine-6-glucuronide (M6G). The sulfation pathway has attracted much less attention but may also form active metabolites. The aim of the pres...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186450/ https://www.ncbi.nlm.nih.gov/pubmed/25505615 http://dx.doi.org/10.1002/prp2.71 |