Use of a novel rapid and resource-efficient cassette dosing approach to determine the pharmacokinetics and CNS distribution of small molecule 7-transmembrane receptor allosteric modulators in rat

Approaches to efficiently and accurately define the pharmacokinetics (PK) of large sets of small molecules in rodents have been previously described. Likewise, a variety of methods for determining brain tissue distribution (BTD) have been reported for use in the discovery of therapeutics targeting t...

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Detalles Bibliográficos
Autores principales: Bridges, Thomas M, Morrison, Ryan D, Byers, Frank W, Luo, Shuanghui, Scott Daniels, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186453/
https://www.ncbi.nlm.nih.gov/pubmed/25505618
http://dx.doi.org/10.1002/prp2.77

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