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Selective IAP inhibition results in sensitization of unstimulated but not CD40-stimulated chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis

Despite recent advances in therapy, chronic lymphocytic leukaemia (CLL) remains incurable and new treatment strategies are therefore urgently required. Inhibitor of apoptosis proteins (IAPs) are over-expressed in CLL, suggesting both a role in disease pathogenesis and the potential for therapeutic t...

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Detalles Bibliográficos
Autores principales:	Zhuang, Jianguo, Laing, Naomi, Oates, Melanie, Lin, Ke, Johnson, Gillian, Pettitt, Andrew R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186455/ https://www.ncbi.nlm.nih.gov/pubmed/25505620 http://dx.doi.org/10.1002/prp2.81

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