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Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states

PURPOSE: Adverse childhood experiences (ACEs) before age 18 have been repeatedly associated with several chronic diseases in adulthood such as depression, heart disease, cancer, diabetes, and stroke. We examined sex-specific relationships between individual ACEs and the number of ACEs with chronic o...

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Autores principales: Cunningham, Timothy J, Ford, Earl S, Croft, Janet B, Merrick, Melissa T, Rolle, Italia V, Giles, Wayne H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186575/
https://www.ncbi.nlm.nih.gov/pubmed/25298732
http://dx.doi.org/10.2147/COPD.S68226
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author Cunningham, Timothy J
Ford, Earl S
Croft, Janet B
Merrick, Melissa T
Rolle, Italia V
Giles, Wayne H
author_facet Cunningham, Timothy J
Ford, Earl S
Croft, Janet B
Merrick, Melissa T
Rolle, Italia V
Giles, Wayne H
author_sort Cunningham, Timothy J
collection PubMed
description PURPOSE: Adverse childhood experiences (ACEs) before age 18 have been repeatedly associated with several chronic diseases in adulthood such as depression, heart disease, cancer, diabetes, and stroke. We examined sex-specific relationships between individual ACEs and the number of ACEs with chronic obstructive pulmonary disease (COPD) in the general population. MATERIALS AND METHODS: Data from 26,546 women and 19,015 men aged ≥18 years in five states of the 2011 Behavioral Risk Factor Surveillance System were analyzed. We used log-linear regression to estimate prevalence ratios (PRs) and their corresponding 95% confidence intervals (CIs) for the relationship of eight ACEs with COPD after adjustment for age group, race/ethnicity, marital status, educational attainment, employment, asthma history, health insurance coverage, and smoking status. RESULTS: Some 63.8% of women and 62.2% of men reported ≥1 ACE. COPD was reported by 4.9% of women and 4.0% of men. In women, but not in men, there was a higher likelihood of COPD associated with verbal abuse (PR =1.30, 95% CI: 1.05, 1.61), sexual abuse (PR =1.69, 95% CI: 1.36, 2.10), living with a substance abusing household member (PR =1.49, 95% CI: 1.23, 1.81), witnessing domestic violence (PR =1.40, 95% CI: 1.14, 1.72), and parental separation/divorce (PR =1.47, 95% CI: 1.21, 1.80) during childhood compared to those with no individual ACEs. Reporting ≥5 ACEs (PR =2.08, 95% CI: 1.55, 2.80) compared to none was associated with a higher likelihood of COPD among women only. CONCLUSION: ACEs are related to COPD, especially among women. These findings underscore the need for further research that examines sex-specific differences and the possible mechanisms linking ACEs and COPD. This work adds to a growing body of research suggesting that ACEs may contribute to health problems later in life and suggesting a need for program and policy solutions.
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spelling pubmed-41865752014-10-08 Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states Cunningham, Timothy J Ford, Earl S Croft, Janet B Merrick, Melissa T Rolle, Italia V Giles, Wayne H Int J Chron Obstruct Pulmon Dis Original Research PURPOSE: Adverse childhood experiences (ACEs) before age 18 have been repeatedly associated with several chronic diseases in adulthood such as depression, heart disease, cancer, diabetes, and stroke. We examined sex-specific relationships between individual ACEs and the number of ACEs with chronic obstructive pulmonary disease (COPD) in the general population. MATERIALS AND METHODS: Data from 26,546 women and 19,015 men aged ≥18 years in five states of the 2011 Behavioral Risk Factor Surveillance System were analyzed. We used log-linear regression to estimate prevalence ratios (PRs) and their corresponding 95% confidence intervals (CIs) for the relationship of eight ACEs with COPD after adjustment for age group, race/ethnicity, marital status, educational attainment, employment, asthma history, health insurance coverage, and smoking status. RESULTS: Some 63.8% of women and 62.2% of men reported ≥1 ACE. COPD was reported by 4.9% of women and 4.0% of men. In women, but not in men, there was a higher likelihood of COPD associated with verbal abuse (PR =1.30, 95% CI: 1.05, 1.61), sexual abuse (PR =1.69, 95% CI: 1.36, 2.10), living with a substance abusing household member (PR =1.49, 95% CI: 1.23, 1.81), witnessing domestic violence (PR =1.40, 95% CI: 1.14, 1.72), and parental separation/divorce (PR =1.47, 95% CI: 1.21, 1.80) during childhood compared to those with no individual ACEs. Reporting ≥5 ACEs (PR =2.08, 95% CI: 1.55, 2.80) compared to none was associated with a higher likelihood of COPD among women only. CONCLUSION: ACEs are related to COPD, especially among women. These findings underscore the need for further research that examines sex-specific differences and the possible mechanisms linking ACEs and COPD. This work adds to a growing body of research suggesting that ACEs may contribute to health problems later in life and suggesting a need for program and policy solutions. Dove Medical Press 2014-09-26 /pmc/articles/PMC4186575/ /pubmed/25298732 http://dx.doi.org/10.2147/COPD.S68226 Text en © 2014 Cunningham et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Cunningham, Timothy J
Ford, Earl S
Croft, Janet B
Merrick, Melissa T
Rolle, Italia V
Giles, Wayne H
Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
title Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
title_full Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
title_fullStr Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
title_full_unstemmed Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
title_short Sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
title_sort sex-specific relationships between adverse childhood experiences and chronic obstructive pulmonary disease in five states
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186575/
https://www.ncbi.nlm.nih.gov/pubmed/25298732
http://dx.doi.org/10.2147/COPD.S68226
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