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MACC1 expression levels as a novel prognostic marker for colorectal cancer
Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types o...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186624/ https://www.ncbi.nlm.nih.gov/pubmed/25295116 http://dx.doi.org/10.3892/ol.2014.2460 |
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author | YAMAMOTO, HIROFUMI MIYOSHI, NORIKATSU MIMORI, KOSHI HITORA, TOSHIKI TOKUOKA, MASAYOSHI FUJINO, SHIKI ELLIS, HALEY L. ISHII, HIDESHI NOURA, SHINGO OHUE, MASAYUKI YANO, MASAHIKO DOKI, YUICHIRO MORI, MASAKI |
author_facet | YAMAMOTO, HIROFUMI MIYOSHI, NORIKATSU MIMORI, KOSHI HITORA, TOSHIKI TOKUOKA, MASAYOSHI FUJINO, SHIKI ELLIS, HALEY L. ISHII, HIDESHI NOURA, SHINGO OHUE, MASAYUKI YANO, MASAHIKO DOKI, YUICHIRO MORI, MASAKI |
author_sort | YAMAMOTO, HIROFUMI |
collection | PubMed |
description | Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients. |
format | Online Article Text |
id | pubmed-4186624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-41866242014-10-07 MACC1 expression levels as a novel prognostic marker for colorectal cancer YAMAMOTO, HIROFUMI MIYOSHI, NORIKATSU MIMORI, KOSHI HITORA, TOSHIKI TOKUOKA, MASAYOSHI FUJINO, SHIKI ELLIS, HALEY L. ISHII, HIDESHI NOURA, SHINGO OHUE, MASAYUKI YANO, MASAHIKO DOKI, YUICHIRO MORI, MASAKI Oncol Lett Articles Metastasis-associated in colon cancer-1 (MACC1) is key in promoting tumor proliferation and invasion, and is mediated by the hepatocyte growth factor (HGF) and mesenchymal-epithelial transition factor. Previous reports have revealed that MACC1 is a novel oncogene that is expressed in various types of gastrointestinal cancer. The present study comprised of 174 patients who underwent curative surgery for colorectal cancer (CRC). The correlation between gene expression and clinical parameters of the patients was assessed. It was identified that patients exhibiting high MACC1 expression levels were statistically more susceptible to distant metastases and a poor prognosis, and those exhibiting low MACC1 expression showed improved disease-free and overall survival than those with high expression. Therefore, the present data indicates that MACC1 expression levels may present as a prognostic factor in CRC patients. D.A. Spandidos 2014-11 2014-08-19 /pmc/articles/PMC4186624/ /pubmed/25295116 http://dx.doi.org/10.3892/ol.2014.2460 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles YAMAMOTO, HIROFUMI MIYOSHI, NORIKATSU MIMORI, KOSHI HITORA, TOSHIKI TOKUOKA, MASAYOSHI FUJINO, SHIKI ELLIS, HALEY L. ISHII, HIDESHI NOURA, SHINGO OHUE, MASAYUKI YANO, MASAHIKO DOKI, YUICHIRO MORI, MASAKI MACC1 expression levels as a novel prognostic marker for colorectal cancer |
title | MACC1 expression levels as a novel prognostic marker for colorectal cancer |
title_full | MACC1 expression levels as a novel prognostic marker for colorectal cancer |
title_fullStr | MACC1 expression levels as a novel prognostic marker for colorectal cancer |
title_full_unstemmed | MACC1 expression levels as a novel prognostic marker for colorectal cancer |
title_short | MACC1 expression levels as a novel prognostic marker for colorectal cancer |
title_sort | macc1 expression levels as a novel prognostic marker for colorectal cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186624/ https://www.ncbi.nlm.nih.gov/pubmed/25295116 http://dx.doi.org/10.3892/ol.2014.2460 |
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