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The Presence of Fast-Exchanging Proton Species in Aqueous Solutions of paraCEST Agents Can Impact Rate Constants Measured for Slower Exchanging Species When Fitting CEST Spectra to the Bloch Equations

[Image: see text] LnDOTA-tetraamide complexes typically exist in solution as a mixture of square-antiprismatic (SAP) and twisted square-antiprismatic (TSAP) coordination isomers. In most cases, the SAP isomer, which is preferred for CEST imaging, predominates, and the presence of the minor TSAP isom...

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Detalles Bibliográficos
Autores principales: Evbuomwan, Osasere M., Lee, Joohwan, Woods, Mark, Sherry, A. Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186665/
https://www.ncbi.nlm.nih.gov/pubmed/25210979
http://dx.doi.org/10.1021/ic501290q