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Structure-Based Prediction of Drug Distribution Across the Headgroup and Core Strata of a Phospholipid Bilayer Using Surrogate Phases

[Image: see text] Solvation of drugs in the core (C) and headgroup (H) strata of phospholipid bilayers affects their physiological transport rates and accumulation. These characteristics, especially a complete drug distribution profile across the bilayer strata, are tedious to obtain experimentally,...

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Detalles Bibliográficos
Autores principales:	Natesan, Senthil, Lukacova, Viera, Peng, Ming, Subramaniam, Rajesh, Lynch, Sandra, Wang, Zhanbin, Tandlich, Roman, Balaz, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186683/ https://www.ncbi.nlm.nih.gov/pubmed/25179490 http://dx.doi.org/10.1021/mp5003366

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