Advances in epigenome-wide association studies for common diseases

Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent...

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Detalles Bibliográficos
Autores principales: Paul, Dirk S., Beck, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2014
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186777/
https://www.ncbi.nlm.nih.gov/pubmed/25092140
http://dx.doi.org/10.1016/j.molmed.2014.07.002
Descripción
Sumario:Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this emerging line of research and discuss key challenges for current and future studies.

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