Advances in epigenome-wide association studies for common diseases

Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent...

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Detalles Bibliográficos
Autores principales: Paul, Dirk S., Beck, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2014
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186777/
https://www.ncbi.nlm.nih.gov/pubmed/25092140
http://dx.doi.org/10.1016/j.molmed.2014.07.002
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author Paul, Dirk S.
Beck, Stephan
author_facet Paul, Dirk S.
Beck, Stephan
author_sort Paul, Dirk S.
collection PubMed
description Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this emerging line of research and discuss key challenges for current and future studies.
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spelling pubmed-41867772014-10-13 Advances in epigenome-wide association studies for common diseases Paul, Dirk S. Beck, Stephan Trends Mol Med Spotlight Epigenome-wide association studies (EWASs) provide a systematic approach to uncovering epigenetic variants underlying common diseases. Discoveries have shed light on novel molecular mechanisms of disease and enabled the application of epigenetic variants as biomarkers. Here, we highlight the recent advances in this emerging line of research and discuss key challenges for current and future studies. Elsevier Science Ltd 2014-10 /pmc/articles/PMC4186777/ /pubmed/25092140 http://dx.doi.org/10.1016/j.molmed.2014.07.002 Text en © 2014 The Authors https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/) .
spellingShingle Spotlight
Paul, Dirk S.
Beck, Stephan
Advances in epigenome-wide association studies for common diseases
title Advances in epigenome-wide association studies for common diseases
title_full Advances in epigenome-wide association studies for common diseases
title_fullStr Advances in epigenome-wide association studies for common diseases
title_full_unstemmed Advances in epigenome-wide association studies for common diseases
title_short Advances in epigenome-wide association studies for common diseases
title_sort advances in epigenome-wide association studies for common diseases
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186777/
https://www.ncbi.nlm.nih.gov/pubmed/25092140
http://dx.doi.org/10.1016/j.molmed.2014.07.002
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