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Structural and Energetic Effects of A(2A) Adenosine Receptor Mutations on Agonist and Antagonist Binding

To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow interpretation and prediction of individual responses...

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Detalles Bibliográficos
Autores principales:	Keränen, Henrik, Gutiérrez-de-Terán, Hugo, Åqvist, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186821/ https://www.ncbi.nlm.nih.gov/pubmed/25285959 http://dx.doi.org/10.1371/journal.pone.0108492

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