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Mesenchymal stem cell therapy and acute graft-versus-host disease: a review

Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, pa...

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Autores principales: Amorin, Bruna, Alegretti, Ana Paula, Valim, Vanessa, Pezzi, Annelise, Laureano, Alvaro Macedo, da Silva, Maria Aparecida Lima, Wieck, Andréa, Silla, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186969/
https://www.ncbi.nlm.nih.gov/pubmed/24903975
http://dx.doi.org/10.1007/s13577-014-0095-x
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author Amorin, Bruna
Alegretti, Ana Paula
Valim, Vanessa
Pezzi, Annelise
Laureano, Alvaro Macedo
da Silva, Maria Aparecida Lima
Wieck, Andréa
Silla, Lucia
author_facet Amorin, Bruna
Alegretti, Ana Paula
Valim, Vanessa
Pezzi, Annelise
Laureano, Alvaro Macedo
da Silva, Maria Aparecida Lima
Wieck, Andréa
Silla, Lucia
author_sort Amorin, Bruna
collection PubMed
description Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, particularly in the treatment of conditions involving autoimmune and inflammatory components. Nevertheless, many research findings are still contradictory, mostly due to difficulties in characterization of the effects of MSCs in vivo. The purpose of this review is to report the mechanisms underlying mesenchymal stem cell therapy for acute graft-versus-host disease, particularly with respect to immunomodulation, migration, and homing, as well as report clinical applications described in the literature.
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spelling pubmed-41869692014-10-09 Mesenchymal stem cell therapy and acute graft-versus-host disease: a review Amorin, Bruna Alegretti, Ana Paula Valim, Vanessa Pezzi, Annelise Laureano, Alvaro Macedo da Silva, Maria Aparecida Lima Wieck, Andréa Silla, Lucia Hum Cell Review Article Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, particularly in the treatment of conditions involving autoimmune and inflammatory components. Nevertheless, many research findings are still contradictory, mostly due to difficulties in characterization of the effects of MSCs in vivo. The purpose of this review is to report the mechanisms underlying mesenchymal stem cell therapy for acute graft-versus-host disease, particularly with respect to immunomodulation, migration, and homing, as well as report clinical applications described in the literature. Springer Japan 2014-06-06 2014 /pmc/articles/PMC4186969/ /pubmed/24903975 http://dx.doi.org/10.1007/s13577-014-0095-x Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Amorin, Bruna
Alegretti, Ana Paula
Valim, Vanessa
Pezzi, Annelise
Laureano, Alvaro Macedo
da Silva, Maria Aparecida Lima
Wieck, Andréa
Silla, Lucia
Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
title Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
title_full Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
title_fullStr Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
title_full_unstemmed Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
title_short Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
title_sort mesenchymal stem cell therapy and acute graft-versus-host disease: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186969/
https://www.ncbi.nlm.nih.gov/pubmed/24903975
http://dx.doi.org/10.1007/s13577-014-0095-x
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