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Mesenchymal stem cell therapy and acute graft-versus-host disease: a review
Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, pa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186969/ https://www.ncbi.nlm.nih.gov/pubmed/24903975 http://dx.doi.org/10.1007/s13577-014-0095-x |
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author | Amorin, Bruna Alegretti, Ana Paula Valim, Vanessa Pezzi, Annelise Laureano, Alvaro Macedo da Silva, Maria Aparecida Lima Wieck, Andréa Silla, Lucia |
author_facet | Amorin, Bruna Alegretti, Ana Paula Valim, Vanessa Pezzi, Annelise Laureano, Alvaro Macedo da Silva, Maria Aparecida Lima Wieck, Andréa Silla, Lucia |
author_sort | Amorin, Bruna |
collection | PubMed |
description | Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, particularly in the treatment of conditions involving autoimmune and inflammatory components. Nevertheless, many research findings are still contradictory, mostly due to difficulties in characterization of the effects of MSCs in vivo. The purpose of this review is to report the mechanisms underlying mesenchymal stem cell therapy for acute graft-versus-host disease, particularly with respect to immunomodulation, migration, and homing, as well as report clinical applications described in the literature. |
format | Online Article Text |
id | pubmed-4186969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-41869692014-10-09 Mesenchymal stem cell therapy and acute graft-versus-host disease: a review Amorin, Bruna Alegretti, Ana Paula Valim, Vanessa Pezzi, Annelise Laureano, Alvaro Macedo da Silva, Maria Aparecida Lima Wieck, Andréa Silla, Lucia Hum Cell Review Article Mesenchymal stem cells (MSCs) are being widely studied as potential cell therapy agents due to their immunomodulatory properties, which have been established by in vitro studies and in several clinical trials. Within this context, mesenchymal stem cell therapy appears to hold substantial promise, particularly in the treatment of conditions involving autoimmune and inflammatory components. Nevertheless, many research findings are still contradictory, mostly due to difficulties in characterization of the effects of MSCs in vivo. The purpose of this review is to report the mechanisms underlying mesenchymal stem cell therapy for acute graft-versus-host disease, particularly with respect to immunomodulation, migration, and homing, as well as report clinical applications described in the literature. Springer Japan 2014-06-06 2014 /pmc/articles/PMC4186969/ /pubmed/24903975 http://dx.doi.org/10.1007/s13577-014-0095-x Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Article Amorin, Bruna Alegretti, Ana Paula Valim, Vanessa Pezzi, Annelise Laureano, Alvaro Macedo da Silva, Maria Aparecida Lima Wieck, Andréa Silla, Lucia Mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
title | Mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
title_full | Mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
title_fullStr | Mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
title_full_unstemmed | Mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
title_short | Mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
title_sort | mesenchymal stem cell therapy and acute graft-versus-host disease: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186969/ https://www.ncbi.nlm.nih.gov/pubmed/24903975 http://dx.doi.org/10.1007/s13577-014-0095-x |
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