Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction

An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N’-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described. Various trifluoromethylated pyrazolo[5,1-a]isoquinolines were afforde...

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Autores principales: Zhou, Xiaoli, Liu, Meiling, Luo, Puying, Lai, Yingjun, Yang, Tangtao, Ding, Qiuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187034/
https://www.ncbi.nlm.nih.gov/pubmed/25298796
http://dx.doi.org/10.3762/bjoc.10.238
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author Zhou, Xiaoli
Liu, Meiling
Luo, Puying
Lai, Yingjun
Yang, Tangtao
Ding, Qiuping
author_facet Zhou, Xiaoli
Liu, Meiling
Luo, Puying
Lai, Yingjun
Yang, Tangtao
Ding, Qiuping
author_sort Zhou, Xiaoli
collection PubMed
description An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N’-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described. Various trifluoromethylated pyrazolo[5,1-a]isoquinolines were afforded in moderate to excellent yield by this developed method.
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spelling pubmed-41870342014-10-08 Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction Zhou, Xiaoli Liu, Meiling Luo, Puying Lai, Yingjun Yang, Tangtao Ding, Qiuping Beilstein J Org Chem Full Research Paper An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N’-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described. Various trifluoromethylated pyrazolo[5,1-a]isoquinolines were afforded in moderate to excellent yield by this developed method. Beilstein-Institut 2014-09-30 /pmc/articles/PMC4187034/ /pubmed/25298796 http://dx.doi.org/10.3762/bjoc.10.238 Text en Copyright © 2014, Zhou et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Zhou, Xiaoli
Liu, Meiling
Luo, Puying
Lai, Yingjun
Yang, Tangtao
Ding, Qiuping
Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
title Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
title_full Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
title_fullStr Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
title_full_unstemmed Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
title_short Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
title_sort synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187034/
https://www.ncbi.nlm.nih.gov/pubmed/25298796
http://dx.doi.org/10.3762/bjoc.10.238
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