A modular phosphate tether-mediated divergent strategy to complex polyols

An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pse...

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Autores principales: Hanson, Paul R, Jayasinghe, Susanthi, Maitra, Soma, Ndi, Cornelius N, Chegondi, Rambabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187035/
https://www.ncbi.nlm.nih.gov/pubmed/25298800
http://dx.doi.org/10.3762/bjoc.10.242
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author Hanson, Paul R
Jayasinghe, Susanthi
Maitra, Soma
Ndi, Cornelius N
Chegondi, Rambabu
author_facet Hanson, Paul R
Jayasinghe, Susanthi
Maitra, Soma
Ndi, Cornelius N
Chegondi, Rambabu
author_sort Hanson, Paul R
collection PubMed
description An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pseudo-C(2)-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.
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spelling pubmed-41870352014-10-08 A modular phosphate tether-mediated divergent strategy to complex polyols Hanson, Paul R Jayasinghe, Susanthi Maitra, Soma Ndi, Cornelius N Chegondi, Rambabu Beilstein J Org Chem Full Research Paper An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple “order of addition” of a pair of olefinic-alcohol components to a pseudo-C(2)-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery. Beilstein-Institut 2014-10-07 /pmc/articles/PMC4187035/ /pubmed/25298800 http://dx.doi.org/10.3762/bjoc.10.242 Text en Copyright © 2014, Hanson et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Hanson, Paul R
Jayasinghe, Susanthi
Maitra, Soma
Ndi, Cornelius N
Chegondi, Rambabu
A modular phosphate tether-mediated divergent strategy to complex polyols
title A modular phosphate tether-mediated divergent strategy to complex polyols
title_full A modular phosphate tether-mediated divergent strategy to complex polyols
title_fullStr A modular phosphate tether-mediated divergent strategy to complex polyols
title_full_unstemmed A modular phosphate tether-mediated divergent strategy to complex polyols
title_short A modular phosphate tether-mediated divergent strategy to complex polyols
title_sort modular phosphate tether-mediated divergent strategy to complex polyols
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187035/
https://www.ncbi.nlm.nih.gov/pubmed/25298800
http://dx.doi.org/10.3762/bjoc.10.242
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