(CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones

A very simple and convenient reaction for 1,3-diketone preparation from carboxylic acids and aromatic ketones in TFAA/TfOH system is described. When the β-phenylpropionic acids were used as starting materials, they initially gave 1-indanones and then underwent further acylation with the formation of...

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Detalles Bibliográficos
Autores principales: Kim, JungKeun, Shokova, Elvira, Tafeenko, Victor, Kovalev, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187061/
https://www.ncbi.nlm.nih.gov/pubmed/25298794
http://dx.doi.org/10.3762/bjoc.10.236
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author Kim, JungKeun
Shokova, Elvira
Tafeenko, Victor
Kovalev, Vladimir
author_facet Kim, JungKeun
Shokova, Elvira
Tafeenko, Victor
Kovalev, Vladimir
author_sort Kim, JungKeun
collection PubMed
description A very simple and convenient reaction for 1,3-diketone preparation from carboxylic acids and aromatic ketones in TFAA/TfOH system is described. When the β-phenylpropionic acids were used as starting materials, they initially gave 1-indanones and then underwent further acylation with the formation of 2-(β-phenylpropionyl)-1-indanones as the main reaction products. In addition, the application of the proposed protocol allowed for the synthesis of selected polysubstituted pyrazoles in a one-pot procedure directly from acids and ketones.
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spelling pubmed-41870612014-10-08 (CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones Kim, JungKeun Shokova, Elvira Tafeenko, Victor Kovalev, Vladimir Beilstein J Org Chem Full Research Paper A very simple and convenient reaction for 1,3-diketone preparation from carboxylic acids and aromatic ketones in TFAA/TfOH system is described. When the β-phenylpropionic acids were used as starting materials, they initially gave 1-indanones and then underwent further acylation with the formation of 2-(β-phenylpropionyl)-1-indanones as the main reaction products. In addition, the application of the proposed protocol allowed for the synthesis of selected polysubstituted pyrazoles in a one-pot procedure directly from acids and ketones. Beilstein-Institut 2014-09-26 /pmc/articles/PMC4187061/ /pubmed/25298794 http://dx.doi.org/10.3762/bjoc.10.236 Text en Copyright © 2014, Kim et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Kim, JungKeun
Shokova, Elvira
Tafeenko, Victor
Kovalev, Vladimir
(CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
title (CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
title_full (CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
title_fullStr (CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
title_full_unstemmed (CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
title_short (CF(3)CO)(2)O/CF(3)SO(3)H-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
title_sort (cf(3)co)(2)o/cf(3)so(3)h-mediated synthesis of 1,3-diketones from carboxylic acids and aromatic ketones
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187061/
https://www.ncbi.nlm.nih.gov/pubmed/25298794
http://dx.doi.org/10.3762/bjoc.10.236
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