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Association of Hashimoto's thyroiditis with thyroid cancer

This prospective study investigates the relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) in patients with thyroid nodules (TNs). We prospectively examined 2100 patients with 2753 TNs between January 5, 2010 and August 15, 2013. A total of 2023 patients with 2669 TNs met...

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Autores principales: Azizi, G, Keller, J M, Lewis, M, Piper, K, Puett, D, Rivenbark, K M, Malchoff, C D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187247/
https://www.ncbi.nlm.nih.gov/pubmed/25217233
http://dx.doi.org/10.1530/ERC-14-0258
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author Azizi, G
Keller, J M
Lewis, M
Piper, K
Puett, D
Rivenbark, K M
Malchoff, C D
author_facet Azizi, G
Keller, J M
Lewis, M
Piper, K
Puett, D
Rivenbark, K M
Malchoff, C D
author_sort Azizi, G
collection PubMed
description This prospective study investigates the relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) in patients with thyroid nodules (TNs). We prospectively examined 2100 patients with 2753 TNs between January 5, 2010 and August 15, 2013. A total of 2023 patients with 2669 TNs met the inclusion criteria of TN ≥5 mm and age ≥18 years. Each patient had blood drawn before fine-needle aspiration biopsy (FNAB) for the following measurements: TSH, free thyroxine, free tri-iodothyronine, thyroid peroxidase antibody (TPOAb), and antithyroglobulin antibody (TgAb). Diagnosis of TC was based on pathology analysis of thyroidectomy tissue. The associations of TC with the independent variables were determined by univariate and multivariate logistic regression analysis and reported as adjusted odds ratio (OR) with 95% CI. A total of 248 malignant nodules were found in 233 patients. There was an association of TC with both increased serum TgAb concentration and age<45 years. An elevated serum TgAb concentration was found in 10.2% of patients (182 of 1790) with benign nodules as compared with 20.6% of patients (48 of 233) with malignant nodules (P≤0.0001). TgAb (OR=2.24: CI=1.57, 3.19) and TSH ≥1 μIU/ml (OR (95% CI)) OR: 1.49 (1.09, 2.03) were significant predictors of TC in multivariate analysis controlling for age and gender. TC was not associated with serum concentrations of TPOAb. In patients with TN, elevated serum concentration of TgAb and TSH ≥1 μIU/ml are independent predictors for TC. The association between HT and TC is antibody specific.
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spelling pubmed-41872472014-12-01 Association of Hashimoto's thyroiditis with thyroid cancer Azizi, G Keller, J M Lewis, M Piper, K Puett, D Rivenbark, K M Malchoff, C D Endocr Relat Cancer Research This prospective study investigates the relationship between Hashimoto's thyroiditis (HT) and thyroid cancer (TC) in patients with thyroid nodules (TNs). We prospectively examined 2100 patients with 2753 TNs between January 5, 2010 and August 15, 2013. A total of 2023 patients with 2669 TNs met the inclusion criteria of TN ≥5 mm and age ≥18 years. Each patient had blood drawn before fine-needle aspiration biopsy (FNAB) for the following measurements: TSH, free thyroxine, free tri-iodothyronine, thyroid peroxidase antibody (TPOAb), and antithyroglobulin antibody (TgAb). Diagnosis of TC was based on pathology analysis of thyroidectomy tissue. The associations of TC with the independent variables were determined by univariate and multivariate logistic regression analysis and reported as adjusted odds ratio (OR) with 95% CI. A total of 248 malignant nodules were found in 233 patients. There was an association of TC with both increased serum TgAb concentration and age<45 years. An elevated serum TgAb concentration was found in 10.2% of patients (182 of 1790) with benign nodules as compared with 20.6% of patients (48 of 233) with malignant nodules (P≤0.0001). TgAb (OR=2.24: CI=1.57, 3.19) and TSH ≥1 μIU/ml (OR (95% CI)) OR: 1.49 (1.09, 2.03) were significant predictors of TC in multivariate analysis controlling for age and gender. TC was not associated with serum concentrations of TPOAb. In patients with TN, elevated serum concentration of TgAb and TSH ≥1 μIU/ml are independent predictors for TC. The association between HT and TC is antibody specific. Bioscientifica Ltd 2014-12 /pmc/articles/PMC4187247/ /pubmed/25217233 http://dx.doi.org/10.1530/ERC-14-0258 Text en © 2014 The authors http://creativecommons.org/licenses/by/3.0/deed.en_GB This work is licensed under a Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/deed.en_GB)
spellingShingle Research
Azizi, G
Keller, J M
Lewis, M
Piper, K
Puett, D
Rivenbark, K M
Malchoff, C D
Association of Hashimoto's thyroiditis with thyroid cancer
title Association of Hashimoto's thyroiditis with thyroid cancer
title_full Association of Hashimoto's thyroiditis with thyroid cancer
title_fullStr Association of Hashimoto's thyroiditis with thyroid cancer
title_full_unstemmed Association of Hashimoto's thyroiditis with thyroid cancer
title_short Association of Hashimoto's thyroiditis with thyroid cancer
title_sort association of hashimoto's thyroiditis with thyroid cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187247/
https://www.ncbi.nlm.nih.gov/pubmed/25217233
http://dx.doi.org/10.1530/ERC-14-0258
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