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Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel alone

INTRODUCTION: Phosphatidylinositol 3-kinase (PI3K) pathway deregulation (that is PIK3CA mutations and/or phosphatase and tensin homolog (PTEN) loss) has been shown to enhance breast cancer cell survival and confer resistance to chemotherapeutic agents. We studied the prognostic and predictive value...

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Detalles Bibliográficos
Autores principales:	Xu, Binghe, Guan, Zhongzhen, Shen, Zhenzhou, Tong, Zhongshen, Jiang, Zefei, Yang, Junlan, DeSilvio, Michelle, Russo, Mark, Leigh, Meggan, Ellis, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187249/ https://www.ncbi.nlm.nih.gov/pubmed/25056500 http://dx.doi.org/10.1186/s13058-014-0405-y

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