PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors

INTRODUCTION: Triple negative breast cancer (TNBC) is a heterogeneous collection of biologically diverse cancers, which contributes to variable clinical outcomes. Previously, we identified a TNBC subtype that has a luminal phenotype and expresses the androgen receptor (AR+). TNBC cells derived from...

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Detalles Bibliográficos
Autores principales: Lehmann, Brian D, Bauer, Joshua A, Schafer, Johanna M, Pendleton, Christopher S, Tang, Luojia, Johnson, Kimberly C, Chen, Xi, Balko, Justin M, Gómez, Henry, Arteaga, Carlos L, Mills, Gordon B, Sanders, Melinda E, Pietenpol, Jennifer A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187324/
https://www.ncbi.nlm.nih.gov/pubmed/25103565
http://dx.doi.org/10.1186/s13058-014-0406-x

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