Modeling luminal breast cancer heterogeneity: combination therapy to suppress a hormone receptor-negative, cytokeratin 5-positive subpopulation in luminal disease

INTRODUCTION: Many Luminal breast cancers are heterogeneous, containing substantial numbers of estrogen (ER) and progesterone (PR) receptor-negative cells among the ER+ PR+ ones. One such subpopulation we call “Luminobasal” is ER-, PR- and cytokeratin 5 (CK5)-positive. It is not targeted for treatme...

Descripción completa

Detalles Bibliográficos
Autores principales: Knox, Aaron J, Scaling, Allison L, Pinto, Mauricio P, Bliesner, Brian S, Haughian, James M, Abdel-Hafiz, Hany A, Horwitz, Kathryn B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187339/
https://www.ncbi.nlm.nih.gov/pubmed/25116921
http://dx.doi.org/10.1186/s13058-014-0418-6

Ejemplares similares

Ejemplares similares