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An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model
Diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. Thus, the need for precise segmentation of corneal layer boundaries is inevitable. Obviously, manual segmentation is time-consuming and imprecise. In this paper, the Gaussian mixture model...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187352/ https://www.ncbi.nlm.nih.gov/pubmed/25298926 |
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author | Jahromi, Mahdi Kazemian Kafieh, Raheleh Rabbani, Hossein Dehnavi, Alireza Mehri Peyman, Alireza Hajizadeh, Fedra Ommani, Mohammadreza |
author_facet | Jahromi, Mahdi Kazemian Kafieh, Raheleh Rabbani, Hossein Dehnavi, Alireza Mehri Peyman, Alireza Hajizadeh, Fedra Ommani, Mohammadreza |
author_sort | Jahromi, Mahdi Kazemian |
collection | PubMed |
description | Diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. Thus, the need for precise segmentation of corneal layer boundaries is inevitable. Obviously, manual segmentation is time-consuming and imprecise. In this paper, the Gaussian mixture model (GMM) is used for automatic segmentation of three clinically important corneal boundaries on optical coherence tomography (OCT) images. For this purpose, we apply the GMM method in two consequent steps. In the first step, the GMM is applied on the original image to localize the first and the last boundaries. In the next step, gradient response of a contrast enhanced version of the image is fed into another GMM algorithm to obtain a more clear result around the second boundary. Finally, the first boundary is traced toward down to localize the exact location of the second boundary. We tested the performance of the algorithm on images taken from a Heidelberg OCT imaging system. To evaluate our approach, the automatic boundary results are compared with the boundaries that have been segmented manually by two corneal specialists. The quantitative results show that the proposed method segments the desired boundaries with a great accuracy. Unsigned mean errors between the results of the proposed method and the manual segmentation are 0.332, 0.421, and 0.795 for detection of epithelium, Bowman, and endothelium boundaries, respectively. Unsigned mean errors of the inter-observer between two corneal specialists have also a comparable unsigned value of 0.330, 0.398, and 0.534, respectively. |
format | Online Article Text |
id | pubmed-4187352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41873522014-10-08 An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model Jahromi, Mahdi Kazemian Kafieh, Raheleh Rabbani, Hossein Dehnavi, Alireza Mehri Peyman, Alireza Hajizadeh, Fedra Ommani, Mohammadreza J Med Signals Sens Original Article Diagnosis of corneal diseases is possible by measuring and evaluation of corneal thickness in different layers. Thus, the need for precise segmentation of corneal layer boundaries is inevitable. Obviously, manual segmentation is time-consuming and imprecise. In this paper, the Gaussian mixture model (GMM) is used for automatic segmentation of three clinically important corneal boundaries on optical coherence tomography (OCT) images. For this purpose, we apply the GMM method in two consequent steps. In the first step, the GMM is applied on the original image to localize the first and the last boundaries. In the next step, gradient response of a contrast enhanced version of the image is fed into another GMM algorithm to obtain a more clear result around the second boundary. Finally, the first boundary is traced toward down to localize the exact location of the second boundary. We tested the performance of the algorithm on images taken from a Heidelberg OCT imaging system. To evaluate our approach, the automatic boundary results are compared with the boundaries that have been segmented manually by two corneal specialists. The quantitative results show that the proposed method segments the desired boundaries with a great accuracy. Unsigned mean errors between the results of the proposed method and the manual segmentation are 0.332, 0.421, and 0.795 for detection of epithelium, Bowman, and endothelium boundaries, respectively. Unsigned mean errors of the inter-observer between two corneal specialists have also a comparable unsigned value of 0.330, 0.398, and 0.534, respectively. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4187352/ /pubmed/25298926 Text en Copyright: © Journal of Medical Signals & Sensors http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jahromi, Mahdi Kazemian Kafieh, Raheleh Rabbani, Hossein Dehnavi, Alireza Mehri Peyman, Alireza Hajizadeh, Fedra Ommani, Mohammadreza An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model |
title | An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model |
title_full | An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model |
title_fullStr | An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model |
title_full_unstemmed | An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model |
title_short | An Automatic Algorithm for Segmentation of the Boundaries of Corneal Layers in Optical Coherence Tomography Images using Gaussian Mixture Model |
title_sort | automatic algorithm for segmentation of the boundaries of corneal layers in optical coherence tomography images using gaussian mixture model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187352/ https://www.ncbi.nlm.nih.gov/pubmed/25298926 |
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